Robert-Koch-Str. 27 a
+ 49 251-83-55320 (phone)
+ 49 251-83-55551 (fax)
seidenbe@uni-muenster.de

Research Projects

  1. Contribution of CRF and 5-HT in the anterodorsal BNST to phasic and sustained fear in freely behaving mice
  • Lebenslauf

    Persönliche Daten

    Name Thomas Seidenbecher, Priv.-Doz. Dr.
    Dienstadresse Institut für Physiologie I
    Universität Münster
    Robert-Koch-Str. 27 a
    48149 Münster
    Tel. 0251 / 83-55320
    FAX: 0251 / 83-55551
    E-Mail: seidenbe@uni-muenster.de

    Schulausbildung

    1967-1975 Polytechnische Oberschule „Georgi Dimitroff” in Gera
    1975-1979 Erweiterterte Oberschule „Otto Grotewohl” in Gera
    1979 Erlangung der Hochschulreife (Abitur)

    Wehrdienst

    1979-1981 NVA der DDR

    Hochschulausbildung

    1981-1986 Studium der Biologie an der Martin-Luther-Universität Halle/Wittenberg
    Fachrichtung: Ökologie/Tierphysiologie
    Thema: "Biochemische und Histochemische Untersuchungen zum Einfluß unterschiedlicher Gruppengrößen auf die Enzymaktivität der Dipeptidyl-Peptidase IV (EC.3.4.14.5.) und Aminopeptidase M (EC. 3.4.11.2.) in der Niere der Labormaus (Mus musculus, ICR/ Schön.)"
    Abschluß: Diplom-Biologe

    Akademischer Werdegang

    1986-1988 wiss. Mitarbeiter im Institut für Landschaftsforschung und Naturschutz Halle, Außenstelle Finsterwalde
    1989-1990 wiss. Mitarbeiter der Abteilung Systemphysiologie im Bereich Neurophysiologie des Institutes für Neurobiologie und Hirnforschung Magdeburg, Arbeitsaufenthalt am Physiologischen Institut der Medizinischen Akademie Magdeburg
    Okt/Nov 1990 Arbeitsaufenthalt am Department of Neurology der University Kuopio (Finnland)
    1991-1995 wissenschaftlicher Mitarbeiter der Abteilung Neurophysiologie des
    Institutes für Neurobiologie in Magdeburg
    1995 Promotion zum Dr. rer. nat.
    Thema: „Zeitabhängige Modulation der Langzeit- Potenzierung (LTP) im Gyrus dentatus der freibeweglichen Ratte durch appetitive und aversive Stimuli “
    1996-2005 wiss. Mitarbeiter im Institut für Physiologie der Otto-v.-Guericke-Universität Magdeburg
    seit 04/2005 wiss. Mitarbeiter im Institut für Physiologie I, Münster
    2008 Forschungspreis der Westfälischen Wilhems-Universität, Münster
    2017 Habilitation und venia legendi in Physiologie, Medizinische Fakultät, Westfälische Wilhelms-Universität Münster
  • Publikationen

    2017

    1. Cerina M, Narayanan V, Göbel K, Bittner S, Ruck T, Meuth P, Herrmann AM, Stangel M, Gudi V, Skripuletz T, Daldrup T, Wiendl H, Seidenbecher T,  Ehling P, Kleinschnitz C, Pape H-C, Budde T,  Meuth SG (2017)
      The quality of cortical network function recovery depends on localization and degree of axonal demyelination.
      Brain, Behavior and Immunity 59, 103-117. doi: 10.1016/j.bbi.2016.08.014.

    2016

    1. Lange MD, Daldrup T, Remmers F, Szkudlarek HJ, Lesting J, Guggenhuber S, Ruehle S, Jüngling K, Seidenbecher T, Lutz B and Pape H-C (2016)
      Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat.
      Molecular Psychiatry 2016 Oct 4. doi: 10.1038/mp.2016.156. [Epub ahead of print], PMID: 27698427.
    2. Seidenbecher T, Remmes J, Daldrup T, Lesting J, Pape H-C (2016)
      Distinct state anxiety after predictable and unpredictable fear training in mice.
      Behavioural Brain Research 304: 20-23. doi: 10.1016/j.bbr.2016.02.009.
    3. Daldrup T, Lesting J, Meuth P, Seidenbecher T, Pape H-C (2016)
      Neuronal correlates of sustained fear in the anterolateral part of the bed nucleus of stria terminalis
      Neurobiology  of  Learning  and Memory, dx.doi.org/10.1016/j.nlm.2016.03.020
    4. Kohmann D, Lüttjohann A, Seidenbecher T, Coulon P, Pape HC (2016)
      Short term depression of gap junctional coupling in reticular thalamic neurons of absence epileptic rats.
      J Physiol. 594(19), 5695-710. doi: 10.1113/JP271811
    5. Remmes J, Bodden C, Richter SH, Lesting J, Sachser N, Pape  HC, Seidenbecher T (2016)
      Impact of Life History on Fear Memory and Extinction.
      Frontiers Behav. Neurosci. doi.org/10.3389/fnbeh.2016.00185.
    6. Sakalem ME, Seidenbecher T, Zhang M, Saffari R, Kravchenko M, Wördemann S, Diederich K, Schwamborn JC, Zhang W, Ambrée O (2016)
      Environmental enrichment and physical exercise revert behavioral and electrophysiological impairments caused by reduced adult neurogenesis.
      Hippocampus doi: 10.1002/hipo.22669

    2015

    1. M. Cerina, H.J. Szkudlarek, P. Coulon, P. Meuth, T. Kanyshkova, X.V. Nguyen, K. Göbel, T. Seidenbecher, S.G. Meuth, H.-C. Pape, T. Budde (2015)
      Thalamic Kv7 channels: pharmacological properties and activity control during noxious signal processing. Br J Pharmacol. doi: 10.1111/bph.13113
    2. T. Daldrup, J. Remmes, J. Lesting, S. Gaburro, M. Fendt, P. Meuth, V. Kloke, H.-C. Pape, T. Seidenbecher (2015)
      Expression of freezing and fear-potentiated startle during sustained fear in mice. Genes, Brain and Behavior. doi: 10.1111/gbb.12211

    2014

    1. A. Sajadian, S. Esteghamat ,F. Karimzadeh, A. Eshaghabadi, F. Sieg, E.-J. Speckmann, S. Meuth, T. Seidenbecher, T. Budde, A. Gorji (in press)
      Anticonvulsant effect of neural regeneration peptide 2945 on pentylenetetrazol-induced seizures in rats. Neuropeptides doi: 10.1016/j.npep.2014.11.002

    2013

    1. P. Meuth, S. Gaburro, J. Lesting, A. Legler, M. Herty, T. Budde, S.G. Meuth, T. Seidenbecher, B. Lutz, H.-C. Pape;
      Standardizing the analysis of conditioned fear in rodents: a multidimensional software approach.
      Genes Brain Behav. 2013 Apr 8. doi: 10.1111/gbb.12040.
    2. Lesting J, Daldrup T, Narayanan V, Himpe C, Seidenbecher T, Pape HC,
      Directional Theta Coherence in Prefrontal Cortical to Amygdalo-Hippocampal Pathways Signals Fear Extinction. PLoS ONE 8(10): e77707. doi:10.1371/journal.pone.007770 (2013)

    2012

    1. F. Chauveau, M.D. Lange, K. Jüngling, J. Lesting, T. Seidenbecher, H.C. Pape,
      Prevention of stress-impaired fear extinction through neuropeptide S action in the lateral amygdala.
      Neuropsychopharmacology 37(7):1588-99 (2012)
    2. T. Seidenbecher, J. Lesting
      Amygdala-hippocampal Theta Synchronyin Learning, Memory and Disease
      In: Insights Into the Amygdala: Structure, Functions and Implications for Disorders (Neuroanatomy Research at the Leading Edge), Nova Press 2012; Ed.: Deniz-Yilmazer-Hanke

    2011

    1. V. Narayanan, R. S. Heiming, F. Jansen, J. Lesting, N. Sachser, H.-C. Pape, T. Seidenbecher;
      Social Defeat: Impact on Fear Extinction and Amygdala-Prefrontal Cortical Theta Synchrony in 5-HTT Deficient Mice
      PLoS ONE: 6(7): e22600. doi:10.1371/journal.pone.0022600 (2011)
    2. J. Lesting, R.T. Narayanan, C. Kluge, S. Sangha, T. Seidenbecher, H.-C. Pape
      Patterns of Coupled Theta Activity in Amygdala-Hippocampal-Prefrontal Cortical Circuits during Fear Extinction.
      PLoS ONE 6(6): e21714. doi:10.1371/journal.pone.0021714 (2011)
    3. J. Lesting, M. Geiger, R.T. Narayanan, H.-C. Pape & T. Seidenbecher;
      Impaired extinction of fear and maintained amygdala-hippocampal theta synchrony in a mouse model of temporal lobe epilepsy.
      Epilepsia. 52(2):337-46 (2011)
    4. A. Gorji, C. Mittag, P. Shahabi, T. Seidenbecher, H.-C. Pape;
      Seizure-related activity of intralaminar thalamic neurons in a genetic model of absence epilepsy.
      Neurobiol Dis. 2011 Jul;43(1):266-74. Epub 2011 Mar 31.

    2010

    1. H.-C. Pape, K. Jüngling, T. Seidenbecher, J. Lesting & R.K. Reinscheid
      Neuropeptide S: A transmitter system in the brain regulating fear and anxiety.
      Neuropharmacol. 58: 29-34 (2010).
    2. S. Graebenitz, J. Lesting, L. Sosulina, T. Seidenbecher & H.-C. Pape;
      Alteration of NMDA receptor-mediated synaptic interactions in the lateral amygdala associated with seizure activity in a mouse model of chronic temporal lobe epilepsy.
      Epilepsia. 51(9):1754-1762 (2010).
    3. P. Coulon*, T. Kanyshkova*, T. Broicher*, T. Munsch, N. Wettschureck, T. Seidenbecher, S.G. Meuth, S. Offermanns, H.-C. Pape & T. Budde.
      Activity modes in thalamocortical relay neurons are modulated by Gq/G11 family G-proteins – serotonergic and glutamatergic signalling.
      Front Cell Neurosci., accepted for publication. *authors contributed equally

    2009

    1. R.J. Moran, K.E. Stephan, T. Seidenbecher, H.-C. Pape, R.J. Dolan, K.J. Friston
      Dynamic causal models of steady-state responses.
      Neuroimage.  2009: 44(3):796-811
    2. S. Sangha, R.T. Narayanan, J.R. Bergado-Acosta, O. Stork, T. Seidenbecher & H.-C. Pape,
      Deficiency of the 65-kDa isoform of glutamic acid decarboxylase impairs extinction of cued but not contextual fear memory.
      J. Neurosci., 29: 15713-15720 (2009)

    2008

    1. K. Jüngling, T. Seidenbecher, L. Sosulina, J. Lesting, S. Sangha, S. Clark, N. Okamura, D. Duangdao, Y.-L. Xu, R. Reinscheid, H.-C. Pape
      Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala.
      Neuron, 59: 293-310 (2008).
    2. T. Broicher, N. Wettschureck, T. Munsch, P. Coulon, S. Meuth, T. Seidenbecher, S. Offermanns, H.-C. Pape, T. Budde
      Muscarinic ACh receptor-mediated control of thalamic activity via Gq/G11-family G-proteins.
      Pflügers Arch., 456: 1049-1060.

    2007

    1. R.T. Narayanan, T. Seidenbecher, C. Kluge, J. Bergado, O. Stork and H.-C. Pape
      Dissociated theta synchronization in amygdalo-hippocampal circuits during various stages of fear memory.
      Eur. J. Neurosci., 25 (6): 1823–1831 (2007).
    2. R.T. Narayanan, T. Seidenbecher, S. Sangha, O.Stork and H.-C. Pape
      Theta re-synchronization during reconsolidation of remote contextual fear memory.
      NeuroReport, 18(11): 1107-1111 (2007).
    3. T. Broicher, T. Seidenbecher, P. Meuth, T. Munsch, S.G. Meuth, T. Kanyshkova, H.-C. Pape and T. Budde
      T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model absence epilepsy.
      Neuropharmacol., 53(3): 431-446 (2007).

    2006

    1. Meuth S.G., Aller I.M., Munsch T., Schuhmacher T., Seidenbecher T., Meuth P., Kleinschnitz C., Pape H.-C., Wiendl H., Wisden W., and Budde T.
      The contribution of TASK-1-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons.
      Molecular Pharmacology Fast Forward Published January 19, 2006; doi: 10.1124/mol.105.020594
    2. Hentschke M., Wiemann M., Hentschke S., Kurth I., Hermans-Borgmeyer I., T. Seidenbecher , Jentsch T.J., Gal A., Hubner C.A.
      Mice with a Targeted Disruption of the Cl-/HCO3- Exchanger AE3 Display a Reduced Seizure Threshold.
      Mol Cell Biol. 26(1): 182-191 (2006)

    2005

    1. H.-C. Pape, R.T. Narayanan, J. Smid, O. Stork & T. Seidenbecher
      Theta activity in neurons and networks of amygdala related to long-term fear memory.
      Hippocampus. 15: 874-880 (2005)
    2. H.-C. Pape, S.G. Meuth, T. Seidenbecher, T. Munsch & T. Budde,
      Der Thalamus: Tor zum Bewusstsein und Rhythmusgenerator im Gehirn.
      Neuroforum 2.05, 44-54 (2005).

    2004

    1. R. Linke, H. Faber-Zuschratter, T. Seidenbecher & H.-C. Pape
      Axonal connections from posterior paralaminar thalamic neurons to basomedial amygdaloid projection neurons to the lateral entorhinal cortex in rats.
      Brain Res. Bull. 63: 461-469 (2004).

    2003

    1. Seidenbecher T, Laxmi TR, Stork O, Pape HC (2003)
      Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval.
      Science 301(5634):846-50.
    2. Boettger T, Rust MB, Maier H, Seidenbecher T, Schweizer M, Keating DJ, Faulhaber J, Ehmke H, Pfeffer C, Scheel O, Lemcke B, Horst J, Leuwer R, Pape HC, Völkl H, Hübner CA, Jentsch TJ (2003)
      Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.
      Journal  (EMBO J. 22(20):5422-34.

    Book chapters

    1. Seidenbecher T
      Lernen, Gedächtnis und synaptische Plastizität.
      In: “ Fragen und Antworten zu den Neurowissenschaften”, Hrsg. T. Budde & S. Meuth, Verlag Hans Huber (2003)
    2. Seidenbecher T and Lesting J
      Amygdala-Hippocampal Theta Synchrony in Learning, Memory and Disease.
      In: “Insights into the amygdala. Structure, functions and implications for disorders“(Chapter 8), Ed. D. Yilmazer-Hanke, Nova Science Publishers, Inc. (2012)