Program

Thursday, March 10
10.00 - 13.00 Registration and Lunch
13.00 - 14.00 Plenary Lecture
Chair: Jörg Gromoll, Münster
  X-inactivation dynamics - Joost Gribnau, The Netherlands
14.00 - 15.30 X-Chromosome
Chair: Alberto Ferlin, Padua; Gabriel Marais, Lyon
  Increasing prenatal diagnoses of KS: controversies in clinical counselling - Frank Tüttelmann, Germany
  Epigenetic signatures in the brain of KS patients - Joana Viana, UK
  X-chromosome regulation - Christine Disteche, USA
15.30 - 16:00 Coffee
16.00 - 17.30 Animal models on sex chromosomal aneuploidies
Chairs: Stefan Schlatt, Münster; Liborio Stuppia, Chieti
  The Sex Chromosome Trisomy mouse model of XXY and XYY - Art Arnold, USA
  Neuroimaging Genomics of Sex Chromosome Aneuploidy - Armin Raznahan, USA
  The XXY-mouse models and their clinical counterpart - Joachim Wistuba, Germany
17.30 - 19.00 Selected oral communications
  Fertility preservation in Klinefelter boys: an update after 6 years’ experience - Dorien Van Saen, Belgium
  Hypothetical higher setting of hypothalamus pituitary testis axis in infants with non-mosaic Klinefelter Syndrome- Simona Granato, Italy
  A Multidisciplinary Model of Early Fertility Preservation in Klinefelter Patients: Description of a Program - Hooman Sadri-Ardekani, USA
  Expansion of the language phenotype in Klinefelter syndrome and children with XXYY - Jacqueline Frazier, USA
  Disturbed testicular vascularization in 41, XXY* mice: a functional analysis using contrast enhanced ultrasound - Oliver S. Damm, Germany
  Transcriptome analysis of testis tissue from pre-pubertal Klinefelter boys - Sofia Boeg Winge, Denmark
  Klinefelter syndrome co-morbidities induced by increased gene dosage and altered interactome activity - Kirstine Belling, Denmark
  Effects of long-term treatment with testosterone undecanoate injections (TU) in patients diagnosed with Klinefelter’s syndrome (KS) following detection of osteoporosis. Farid Saad, Germany
19.30 - 22.00 Welcome Reception
Friday, March 11
9.00 - 10.30 Disorders of sexual development - DSD
Chairs: Annette Richter-Unruh, Münster; Armin Raznahan, Bethesda
  The evolution of dosage compensation and the implications for human X aneuploidy syndromes - Gabriel Marais, France
  Turner syndrome – the other side of the coin - Claus Gravholt, Denmark
  The European COST Initiative on DSD - Olaf Hiort, Germany
10.30 - 11.00 Coffee
11.00 - 12.30 Metabolic and cardiovascular risks
Chairs: Anders Juul, Copenhagen; Eberhard Nieschlag, Münster
  Cardiovascular risks - Michael Zitzmann, Germany
  Metabolic risks - Anders Bojesen, Denmark
  Osteoporosis risks - Alberto Ferlin, Italy
12.30 - 13.30 Lunch
13.30 - 14.30 Posterpresentation
14.30 - 16.00 Transition care
Chairs: Vicenco Rochira, Modena; Herve Lejeune, Lyon
  Testicular changes during transition - Niels Skakkebæk, Denmark
  Testosterone replacement in infants and young children - Carole Samango-Sprouse, USA
  Transition to adult care for adolescents/emerging adults with Klinefelter syndrome: Much more than just Testosterone - Alan Rogol, USA
16.00 - 16.30 Coffee
16.30 - 18.00 Neuropsychology and cognition
Chairs: Georg Romer, Münster; Sophie Van Rhjin, Leiden
  Neuropsychology and socioeconomic aspects - Anne Skakkebæk, Denmark
  Social cognition and underlying cognitive mechanisms - Hanna Swaab, Netherlands
  Behavioral and social phenotypes in boys with 47,XYY syndrome or 47,XXY Klinefelter syndrome - Nicole Tartaglia, USA
19.00 - 22.00 Dinner
Saturday, March 12
9.00 - 10.30 Spermatogenesis and fertility preservation
Chairs: Ewa Raipert-de Meyts, Copenhagen; Dorien Van Saen, Bruessels
  Transcriptome of KS testis - Liborio Stuppia, Italy
  Fertility preservation in young and adult KS patients - Sabine Kliesch, Gemany
  Klinefelter syndrome and TESE-ICSI - Hervé Lejeune, France
10.30 - 11.00 Coffee
11.00 - 12.30 Optimized treatment for hypogonadism
Chairs: Fred Wu, Manchester; Carole Samango-Sprouse, Washington
  XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management - Anders Juul, Denmark
  hCG and steroidogenesis - Manuela Simoni, Italy
  dsd-LIFE: QoL, satisfaction with care and needs of adolescents and men with Klinefelter syndrome - Birgit Köhler, Germany
12.30 - 13.30 Round table: Klinefelter syndrome current management and challenges
  Eberhard Nieschlag, Germany, plus others
13.30 - 15:00 Lunch and Adjourn