- Current Publications -

 

2012

 

Role of ion channels and transporters in cell migration.

Schwab A, Fabian, Hanley PJ, Stock C.
Physiol Rev. 2012 Oct;92(4):1865-913. doi: 10.1152/physrev.00018.2011.

 

The P2X7 receptor supports both life and death in fibrogenic pancreatic stellate cells.

Haanes KA, Schwab A, Novac I.
PLoS One. 2012;7(12):e51164. doi: 10.1371/journal.pone.0051164. Epub 2012 Dec 17.

 

2013

 

Na+-H+ Exchanger, pH Regulation and Cancer.

Reshkin SJ, Cardone RA, Harguindey S
Recent Pat Anticancer Drug Discov. 2013 Jan 1;8(1):85-99.

 

Ion channels and transporters in cancer: pathophysiology, regulation and clinical potential.

Pedersen SF, Stock C.
Cancer Res. 2013 Mar 15;73(6):1658-61. doi: 10.1158/0008-5472.CAN-12-4188.

 

Cell volume regulation in epithelial physiology and cancer.

Pedersen SF, Hoffmann EK, Novak I.
Front Physiol. 2013 Aug 30;4:233. doi: 10.3389/fphys.2013.00233. eCollection 2013.

 

Calcium-permeable ion channels in control of autophagy and cancer.

Kondratskyi A, Yassine M, Kondratska K, Skryma R, Slomianny C, Prevarskaya.
Front Physiol. 2013 Oct 2;4:272. doi: 10.3389/fphys.2013.00272.

 

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs - an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research.

Harguindey S, Arranz JL, Polo Orozco JD, Rauch C, Fais S, Cardone RA, Reshkin SJ J Transl Med. 2013 Nov 6;11:282. doi: 10.1186/1479-5876-11-282.

 

The Role of TMEM16A (ANO1) and TMEM16F (ANO6) in cell migration.

Jacobsen KS, Zeeberg K, Sauter DR, Poulsen KA, Hoffmann EK, Schwab A.
Pflugers Arch. 2013 Dec;465(12):1753-62. doi: 10.1007/s00424-013-1315-z.

 

2014

 

Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe.

Greco MR, Antelmi E, Busco G, Guerra L, Rubino R, Casavola V, Reshkin SJ, Cardone RA.
Oncol Rep. 2014 Feb;31(2):940-6. doi: 10.3892/or.2013.2923. Epub 2013 Dec 13.

 

Ion transport and cancer: from initiation to metastasis.

Djamgoz MBA, Coombes RC, Schwab A.
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130092.

Potassium channels in cell cycle and cell proliferation.

Urrego D, Tomczak AP, Zahed F, Stühmer W, Pardo LA.
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130094.

Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks?

Prevarskaya N, Ouadid-Ahidouch H, Skryma R, Shuba Y.
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130097.


Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment.

Andersen AP, Moreira JMA, Pedersen SF.
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130098.

 

The chemistry, physiology and pathology of pH in cancer.

Swietach P, Vaughan-Jones RD, Harris AL, Hulikova A.
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130099.

 

Role of pHi, and proton transporters in oncogene-driven neoplastic transformation.

Reshkin SJ, Maria Raffaella Greco MR, Cardone RA.
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130100.

 

Interaction of tumour cells with their microenvironment: ion channels and cell adhesion molecules. A focus on pancreatic cancer.

Arcangeli A, Crociani O, Bencini L.
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130101.

Ion channels and transporters in tumour cell migration and invasion.

Schwab A, Stock C.
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130102.

 

Sensors and effectors of cancer and stroma cell migration.

Nielsen N, Lindemann O, Schwab A.

Br J Pharmacol. 2014, Apr 13. DOI: 10.1111/bph.12721.

 

Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma.

Kondratska K, Kondratskyi A, Yassine M, Lemonnier L, Lepage G,Morabito A, Skryma R, Prevarskaya N.

Biochim Biophys Acta. 2014 Oct; 1843: 2263-9.

 

Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death.

 Kondratskyi A, Yassine M, Slomianny C, Kondratska K, Gordienko D, Dewailly E, Lehen'kyi V, Skryma R, Prevarskaya N.

Cell Death Dis. 2014 Apr 24. 5:e1193.

 

 

Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question.

Alfarouk KO, Verduzco D, Rauch C, Muddathir AK, Adil HH, Elhassan GO, Ibrahim ME, David Polo Orozco J, Cardone RA, Reshkin SJ, Harguindey S
Oncoscience. 2014 Dec 18;1(12):777-802. eCollection 2014.

 

 

Acid-base transport in pancreatic cancer: molecular mechanisms and clinical potential.

Kong SC, Giannuzzo A, Novak I, Pedersen SF
Biochem Cell Biol. 2014 Dec;92(6):449-59. doi: 10.1139/bcb-2014-0078. Epub 2014 Aug 26.

 

TRP channels and STIM/ORAI proteins: Sensors and effectors of cancer and stroma cell migration.

Nielsen N, Lindemann O, Schwab A
Br J Pharmacol. 2014 Dec;171(24):5524-40. doi: 10.1111/bph.12721. Epub 2014 Jul 2.

 

2015

 

A novel NHE1-centered signaling cassette drives epidermal growth factor receptor-dependent pancreatic tumor metastasis and is a target for combination therapy.

Cardone RA, Greco MR, Zeeberg K, Zaccagnino A, Saccomano M, Bellizzi A, Bruns P, Menga M, Pilarsky C, Schwab A, Alves F, Kalthoff H, Casavola V, Reshkin SJ
Neoplasia. 2015 Feb;17(2):155-66. doi: 10.1016/j.neo.2014.12.003.

 

hERG1 channels drive tumour malignancy and may serve as prognostic factor in pancreatic ductal adenocarcinoma.

Lastraioli E, Perrone G, Sette A, Fiore A, Crociani O, Manoli S, D'Amico M, Masselli M, Iorio J, Callea M, Borzomati D, Nappo G, Bartolozzi F, Santini D, Bencini L, Farsi M, Boni L, Di Costanzo F, Schwab A, Onetti Muda A, Coppola R, Arcangeli A
Br J Cancer. 2015 Mar 17;112(6):1076-87. doi: 10.1038/bjc.2015.28.

 

ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC).

Sauter DR, Novak I, Pedersen SF, Larsen EH, Hoffmann EK.
Pflugers Arch. 2015 Jul;467(7):1495-508. doi: 10.1007/s00424-014-1598-8. Epub 2014 Aug 28.

 

The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells.

Giannuzzo A, Pedersen SF, Novak I.
Mol Cancer. 2015 Nov 25;14:203. doi: 10.1186/s12943-015-0472-4.

 

Proton pump inhibitors inhibit pancreatic secretion: role of gastric and non-gastric H+/K+-ATPases.

Wang J, Barbuskaite D, Tozzi M, Giannuzzo A, Sørensen CE, Novak I
PLoS One. 2015 May 18;10(5):e0126432. doi: 10.1371/journal.pone.0126432. eCollection 2015.

 

2016

 

Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance.

Hoffmann EK, Sørensen BH, Sauter DP, Lambert IH.
Channels (Austin). 2015;9(6):380-96. doi: 10.1080/19336950.2015.1089007. Epub 2015 Nov 16.

 

In silico analysis of the transportome in human pancreatic ductal adenocarcinoma.

Zaccagnino A, Pilarsky C, Tawfik D, Sebens S, Trauzold A, Novak I, Schwab A, Kalthoff H
Eur Biophys J. 2016 Oct;45(7):749-763. Epub 2016 Sep 21.

 

Role of TRPC1 channels in pressure-mediated activation of pancreatic stellate cells.

Fels B, Nielsen N, Schwab A
Eur Biophys J. 2016 Oct;45(7):657-670. Epub 2016 Sep 26.

 

Difference in membrane repair capacity between cancer cell lines an a normal cell line.

Frandsen SK, McNeil AK, Novak I, McNeil PL, Gehl J.
J Membr Biol. 2016 Aug;249(4):569-76. doi: 10.1007/s00232-016-9910-5. Epub 2016 Jun 16.

 

Assessment of different 3D culture systems to study tumor phenotype and chemosensitivity in pancreatic ductal adenocarcinoma (PDAC).

Zeeberg K, Cardone RA, Greco MR, Saccomano M, Nøhr-Nielsen A, Alves F, Pedersen SF, Reshkin SJ.
Int J Oncol. 2016 Jul;49(1):243-52. doi: 10.3892/ijo.2016.3513. Epub 2016 May 10.

 

Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma.

Zaccagnino A, Managò A, Leanza L, Gontarewitz A, Linder B, Azzolini M, Biasutto L, Zoratti M, Peruzzo R, Legler K, Trauzold A, Kalthoff H, Szabo I.
Oncotarget. 2016 Nov 26. doi: 10.18632/11299. [Epub ahead of print]

 

Ion channels in control of pancreatic stellate cell migration.

Storck H, Hild B, Schimmelpfennig S, Sargin S, Nielsen N, Zaccagnino A, Budde T, Novak I, Kalthoff H, Schwab A
Oncotarget. 2016 Nov 26. doi: 10.18632/oncotarget.13647.

 

KCa3.1 (IK) modulates pancreatic cancer cell migration, invasion and proliferation: anomalous effects on TRAM-34

Bonito B, Sauter DR, Schwab A, Djamgoz MB, Novak I
Pflugers Arch. 2016 Nov;468(11-12):1865-1875. Epub 2016 Oct 17.

 

Targeting of the P2X7 receptor in pancreatic cancer and stellate cells

Giannuzzo A, Saccomano M, Napp J, Ellegaard M, Alves F, Novak I
Int J Cancer. 2016 Dec 1;139(11):2540-52. doi: 10.1002/ijc.30380. Epub 2016 Aug 29.

 

Preclinical evaluation of near-infrared (NIR) fluorescently labeled cetuximab as a potential tool for fluorescence-guided surgery.

Saccomano M, Dullin C, Alves F, Napp J
Int J Cancer. 2016 Nov 15;139(10):2277-89. doi: 10.1002/ijc.30277. Epub 2016 Aug 16.

 

Identification of KCa3.1 channel as a novel regulator of oxidative phosphorylation in a subset of pancreatic carcinoma cell lines.

Kovalenko I, Glasauer A, Schöckel L, Sauter DR, Ehrmann A, Sohler F, Hägebarth A, Novak I, Christian S
PLoS One. 2016 Aug 5;11(8):e0160658. doi: 10.1371/journal.pone.0160658. eCollection 2016.

 

pH-sensitive K+ channel TREK-1 is a novel target in pancreatic cancer.

Sauter DR, Sørensen CE, Rapedius M, Brüggemann A, Novak I.
Biochim Biophys Acta. 2016 Oct;1862(10):1994-2003. doi: 10.1016/j.bbadis.2016.07.009. Epub 2016 Jul 19.

 

Monocarboxylate transporters MCT1 and MCT4 regulate migration and invasion of pancreatic ductal adenocarcinoma cells.

Kong SC, Nøhr-Nielsen A, Zeeberg K, Reshkin SJ, Hoffmann EK, Novak I, Pedersen SF
Pancreas. 2016 Aug;45(7):1036-47. doi: 10.1097/MPA.0000000000000571.

 

2017

 

Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells.

Dovmark TH, Saccomano M, Hulikova A, Alves F, Swietach P
Oncogene. 2017 Apr 3. doi: 10.10.38/onc.2017.71

 

Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo.

Leanza L, Romio M, Becker KA, Azzolini M, Trentin L, Manago A, Venturini E, Zaccagnino A, Mattarei A, Caccaetto L, Urbani A, Kadow S, Biasutto L, Martini V, Severin F, Perruzzo R, Trimarco V, Egberts JH, Hauser C, Visentin A, Semenzato G, Kalthoff H, Zoratti M, Gulbins E, Paradisi C, Szabo I.

Cancer Cell. 2017 Apr 10. doi: 10.1016/j.ccell.2017.03.003.

 

Alternating pH landscapes shape epithelial cancer inititation and progression: focus on pancreatic cancer.

Pedersen SF, Novac I, Alves F, Schwab A, Pardo LA.
Bioassays. 2017. in press.