Czeh M, Rosenbauer F. Uncovering a new cellular origin for acute myeloid leukemia with lineage plasticity. 2017; Mol. Cell. Oncol. [ahead of print] Review.

Du J, Neuenschwander M, Yu Y, Däbritz JH, Neuendorff NR, Schleich K, Bittner A, Milanovic M, Beuster G, Radetzki S, Specker E, Reimann M, Rosenbauer F, Mathas S, Lohneis P, Hummel M, Dörken B, von Kries JP, Lee S, Schmitt CA. Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma. 2017; Blood 129:71-81

Riemke P, Czeh M, Fischer J, Walter C, Ghani S, Zepper M, Agelopoulos K, Lettermann S, Gebhardt ML, Mah N, Weilemann A, Grau M, Gröning V, Haferlach T, Lenze D, Delwel R, Prinz M, Andrade-Navarro MA, Lenz G, Dugas M, Müller-Tidow C, Rosenbauer F. Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors. 2016; EMBO J. 35:2399-2416

Hagemeyer N, Kierdorf K, Frenzel K, Xue J, Ringelhan M, Abdullah Z, Godin I, Wieghofer P, Costa Jordão MJ, Ulas T, Yorgancioglu G, Rosenbauer F, Knolle PA, Heikenwalder M, Schultze JL, Prinz M. Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation. 2016; EMBO J. 35:1730-44

Schulze I, Rohde C, Scheller-Wendorff M, Bäumer N, Krause A, Herbst F, Riemke P, Hebestreit K, Tschanter P, Lin Q, Linhart H, Godley LA, Glimm H, Dugas M, Wagner W, Berdel WE, Rosenbauer F, Müller-Tidow C. Increased DNA methylation of Dnmt3b targets impairs leukemogenesis. 2016; Blood 127:1575-86

Grajales-Reyes GE, Iwata A, Albring J, Wu X, Tussiwand R, Kc W, Kretzer NM, Briseño CG, Durai V, Bagadia P, Haldar M, Schönheit J, Rosenbauer F, Murphy TL, Murphy KM. Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor. 2015; Nat. Immunol. 16:708-17

Schönheit J, Leutz A, Rosenbauer F. Chromatin dynamics during differentiation of myeloid cells. 2014; J. Mol. Biol. 427:670-87 Review.

van Riel B, Rosenbauer F. Epigenetic control of hematopoiesis: the PU.1 chromatin connection. 2014; Biol. Chem. 395:1265-74

Walter C, Schuetzmann D, Rosenbauer F, Dugas M. Basic4Cseq: an R/Bioconductor package for analyzing 4C-seq data. 2014; Bioinformatics 30:3268-9

Sonnet M, Claus R, Becker N, Zucknick M, Petersen J, Lipka DB, Oakes CC, Andrulis M, Lier A, Milsom MD, Witte T, Gu L, Kim-Wanner SZ, Schirmacher P, Wulfert M, Gattermann N, Lübbert M, Rosenbauer F, Rehli M, Bullinger L, Weichenhan D, Plass C. Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia. 2014; Genome Med. 6:34

Gerlach K, Hwang Y, Nikolaev A, Atreya R, Dornhoff H, Steiner S, Lehr HA, Wirtz S, Vieth M, Waisman A, Rosenbauer F, McKenzie AN, Weigmann B, Neurath MF. TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. 2014; Nat. Immunol. 15:676-86

Scheller M, Schönheit J, Zimmermann K, Leser U, Rosenbauer F, Leutz A. Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance. 2013;  J. Exp. Med. 210:2239-56

Schönheit J, Kuhl C, Gebhardt ML, Fernández Klett F, Riemke P, Scheller M, Huang G, Naumann R, Leutz A, Stocking C, Priller J, Andrade-Navarro MA and Rosenbauer F. PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment. 2013; Cell Rep. 3:1617-28

Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jorda M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G and Tenen DG. Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion
of Adult Hematopoietic Stem Cells. 2013; Mol. Cell 49:934-46

Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Hölscher C, Müller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. 2013; Nat. Neurosci. 16:273-80

Schoofs T, Rohde C, Hebestreit K, Klein HU, Göllner S, Schulze I, Lerdrup M, Dietrich N, Agrawal-Singh S, Witten A, Stoll M, Lengfelder E, Hofmann WK, Schlenke P, Büchner T, Hansen K, Berdel WE, Rosenbauer F, Dugas M, Müller-Tidow C. DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding. 2013; Blood 121:178-87.

Ghani S, Riemke P, Schönheit J, Lenze D, Stumm J, Hoogenkamp M, Lagendijk A, Heinz S, Bonifer C, Bakkers J, Abdelilah-Seyfried S, Hummel M, Rosenbauer F. Macrophage development from hematopoietic stem cells requires PU.1 coordinated microRNA expression. 2011; Blood 118:2275-2284.

Leddin M, Perrod C, Hoogenkamp M, Ghani S, Assi S, Heinz S, Wilson NK, Follows G, Schönheit J, Vockentanz L, Mosamam A, Chen W, Tenen DG, Westhead DR, Göttgens B, Bonifer C, Rosenbauer F. Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells. 2011; Blood 117:2827-2838.

Vockentanz L, Bröske AM, and Rosenbauer F: Uncovering a unique role for DNA methylation in hematopoietic and leukemic stem cells. 2010; Cell Cycle 9:640-641.

Werth M, Walentin K, Aue A, Schönheit J, Wuebken A, Pode-Shakked N, Vilianovitch L, Erdmann B, Dekel B, Bader M, Barasch J, Rosenbauer F, Luft FC, Schmidt-Ott KM. The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex. 2010; Development 37:3835-3845.

Bröske AM, Vockentanz L, Kharazi S, Huska M, Mancini E, Scheller M, Enns A, Prinz M, Jaenisch R, Nerlov C, Leutz A, Andrade-Navarro MA, Jacobsen SEW, Rosenbauer F. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. 2009; Nat. Genet. 41: 1207-1215.

Ebralidze AK, Guibal FC, Steidl U, Zhang P, Lee S, Bartholdy B, Jorda MA, Petkova V, Rosenbauer F, Huang G, Dayaram T, Klupp J, O'Brien KB, Will B, Hoogenkamp M, Borden KL, Bonifer C, Tenen DG. PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element. 2008; Genes Dev. 22: 2085-2092.

Rosenbauer F# and Tenen DG. Transcription factors in myeloid development: Balancing differentiation with transformation. 2007; Nat. Rev. Immunol. 7:105-117. # Corresponding author

Feinberg MW, Wara AK, Cao Z, Lebedeva MA, Rosenbauer F, Iwasaki H, Hirai H, Katz JP, Haspel RL, Gray S, Akashi K, Segre J, Kaestner KH, Tenen DG, Jain MK. The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. 2007; EMBO J. 26: 4138-4148.

Steidl U, Steidl C, Ebralidze A, Chapuy B, Han HJ, Will B, Rosenbauer F, Becker A, Wagner K, Koschmieder S, Kobayashi S, Costa DB, Schulz T, O'brien KB, Verhaak RG, Delwel R, Haase D, Trumper L, Krauter J, Kohwi-Shigematsu T, Griesinger F, Tenen DG. A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia. 2007; J. Clin. Invest. 117:2611-2620.

Rosenbauer F#, Owens BM, Yu L, Tumang JR, Steidl U, Kutok JL, Clayton LK, Wagner K, Scheller M, Iwasaki H, Liu C, Hackanson B, Akashi K, Leutz A, Rothstein TL, Plass C, and Tenen DG. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. 2006; Nat. Genet. 38: 27-37. # Corresponding author

Steidl U, Rosenbauer F, Verhaak RGW, Gu X, Out HH, Bruns I, Steidl C, Costa DB, Klippel S, Wagner K, Aivado M, Kobbe G, Valk PJ, Passegué E, Libermann TA, Delwel R, and Tenen DG. Essential role of Jun family transcription factors in PU.1-induced leukemic stem cells. 2006; Nat. Genet. 38: 1269-1277.

Scheller M, Huelsken J, Rosenbauer F, Taketo MM, Birchmeier W, Tenen DG, and Leutz A. Hematopoietic stem cell and multi lineage defects by beta-catenin activation. 2006; Nat. Immunol. 7: 1037-1047.

Rosenbauer F, Koschmieder S, Steidl U, and Tenen DG. Effect of transcription factor concentrations on leukemic stem cells. 2005; Blood 106: 1519-1524.

Wagner K, Zhang P, Rosenbauer F, Drescher B, Kobayashi S, Radomska HS, Kutok JL, Gilliland DG, Krauter J, Tenen DG. Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy. 2006; Proc. Natl. Acad. Sci. U S A 103: 6338-6343.

Okuno Y*, Huang G*, Rosenbauer F*, Evans E, Radomska HS, Iwasaki H, Akashi K, Moreau-Gachelin F, Li Y, Zhang P, Goettgens B, and Tenen DG. Potential autoregulation of the transcription factor PU.1 by an upstream regulatory element. 2005; Mol. Cell. Biol. 25:2832-2845. * Shared first authors

Koschmieder S, Rosenbauer F, Steidl U, Owens BM, and Tenen DG. Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia. 2005; Int. J. Hematol. 81: 368 – 377.

Rosenbauer F, Wagner K, Kutok JL, Iwasaki H, Le Beau MM, Okuno Y, Akashi K, Fiering S, and Tenen DG. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. 2004; Nat. Genet. 36:624-630.

Rosenbauer F, Wagner K, Zhang P, Knobeloch KP, Iwama A, and Tenen DG. pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1. 2004; Blood 103: 4294-4301.

Rosenbauer F, Kallies A, Scheller M, Knobeloch KP, Rock CO, Schwieger M, Stocking C, and Horak I. Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion. 2002; EMBO J. 21: 211-220.

Kallies A, Rosenbauer F, Scheller M, Knobeloch KP, and Horak I. Accumulation of c-Cbl and rapid termination of CSF-1 receptor signaling in ICSBP-deficient bone marrow-derived macrophages. 2002; Blood 99: 3213-3219.

Rosenbauer F, Waring JF, Foerster J, Wietstruk M, Philipp D, and Horak I. Interferon consensus sequences binding protein and interferon regulatory factor-4/ Pip form a complex that represses the expression of the interferon-stimulated gene-15 in macrophages. 1999; Blood 94:4274-4281.

Schmidt M, Nagel S, Proba J, Thiede C, Waring JF, Rosenbauer F, Huhn D, Wittig B, Horak I, and Neubauer A. Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias. 1998; Blood 91:22-29.

Holtschke T, Lohler J, Kanno Y, Fehr T, Giese N, Rosenbauer F, Lou J, Knobeloch KP, Gabriele L, Waring JF, Bachmann MF, Zinkernagel RM, Morse HC, Ozato K, and Horak I. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. 1996; Cell 87:307-317.