Akademischer Rat des Instituts für Physiologie I


Robert-Koch-Str. 27 a
+ 49 251-83-55416 (phone)
+ 49 251-83-55551 (fax)
kay.juengling@gmx.de

 

Research Projects

  1. Impact of the Neuropeptide S system and NPS-receptor polymorphisms on fear and anxiety
  2. Jün3/003/17 - Jüngling (IZKF)
  • Lebenslauf

    Geburtsdatum: 25.08.1976
    Geburtsort: Bochum, Deutschland
    Familienstand: verheiratet

    Schulausbildung

    1983-1996 Grundschule in Dortmund-Bodelschwingh; Heinrich-Heine Gymniasium in

    Hochschulausbildung

    10/1997-08/2002 Diplomstudiengang der Biologie an der Ruhr-Universität Bochum;
    biologische Fachprüfungen: Zell- und Neurobiologie, Zoologie;
    außerbiologisches Wahlpflichtfach: Biochemie
    Diplomarbeit Titel „Synaptogenese in neuronal differenzierten embryonalen Stammzellen der Maus“; angefertigt im Lehrstuhl für Zellphysiologie der Ruhr-Universität Bochum
    15.08.2002 Diplom in der Biologie an der Ruhr-Universität Bochum
    06.04.2006 Promotion an der Ruhr-Universität Bochum
    08/2002-07/2005 Stipendiat im DFG Graduierten Kolleg 736: „Development and Plasticity of the Nervous System”
    Promotion Titel “Molekulare Mechanismen von Synaptogeneseprozessen“
    Seit 08/2005 Wissenschaftliche Hilfskraft an der Universitätsklinik Düsseldorf,
    Institut für Neurophysiologie
    Seit 01.07.2006 Wissenschaftlicher Angestellter am Universitätsklinikum Münster
    im Institut für Physiologie I
    2008 Forschungspreis der Westfälischen Wilhems-Universität, Münster

    Kongressliste

    2002 Transport-Meeting, Göttingen; Posterpräsentation: “Impaired presynaptic function at glutamatergic synapses in N-cadherin deficient ES cell-derived neurons”
    2003 Molecular basis of CNS disorders, Bonn
    2003 Deutsche Physiologentatgung, Bochum; Posterpräsentation: “Impaired presynaptic function at glutamatergic synapses in N-cadherin deficient ES cell-derived neurons”
    2003 29th Göttingen Neurobiology Conference; Vortrag: ”Regulation of presynaptic function by synaptic adhesion molecules: Role of N-cadherin”
    2003 53rd Meeting of Nobel Prize Winners in Lindau
    2004 International Neuroscience Symposium, Bochum; Posterpräsentation: “Impaired presynaptic function at glutamatergic synapses in N-cadherin deficient ES cell-derived neurons”
    2005 Sixth Meeting of the German Neuroscience Society; Posterpräsentation: “Role of N-cadherin in selective stabilisation of glutamatergic synapses”
    2005 Sixth Meeting of the German Neuroscience Society, 30th Göttingen Neurobiology Conference, Satellite Symposium V „Joint Symposium of the DFG Neuroscience Graduate Schools”; Vortrag: The Role of N-Cadherin in synapse formation and function”
    2008 FENS; Genf. Posterpräsentation:” Neuropeptide S: Modulation of synaptic circuits involved in fear extinction”
  • Publikationen

    2016

    1. Jüngling K, Blaesse P, Goedecke L, Pape HC.
      Dynorphin-dependent reduction of excitability and attenuation of inhibitory afferents of NPS neurons in the pericoerulear region of mice. Front Cell Neurosci 10:61 (2016).
    2. Lange MD, Daldrup T, Remmers F, Szkudlarek HJ, Lesting J, Guggenhuber S, Ruehle S, Jüngling K, Seidenbecher T, Lutz B, Pape HC.
      Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat. Molecular Psychiatry 2016 Oct 4. doi: 10.1038/mp.2016.156. [Epub ahead of print], PMID: 27698427 (2016).

    2015

    1. Erdmann F, Kügler S, Blaesse P, Lange MD, Skryabin BV, Pape HC, Jüngling K.
      Neuronal Expression of the Human Neuropeptide S Receptor NPSR1 Identifies NPS-Induced Calcium Signaling Pathways.
      PLoS One. 2015 Feb 25;10(2):e0117319. doi: 10.1371/journal.pone.0117319. eCollection 2015.
    2. Jüngling K, Lange M, Szkudlarek H, Lesting J, Erdmann F, Doengi M, Kügler S, Pape HC.
      Increased GABAergic efficacy of central amygdala projections to neuropeptide neurons in the brainstem during fear memory retrieval. Neuropsychopharmacoloy, in press (2015). 
    3. Blaesse P, Goedecke L, Bazelot M, Capogna M, Pape HC, Jüngling K.
      µ-opioid receptor-mediated inhibition of intercalated neurons and impact on synaptic transmission to the central amygdala. J. Neurosci., in press (2015).

    2013

    1. Pielarski KN, van Stegen B, Andreyeva A, Nieweg K, Jüngling K, Redies C, Gottmann K.
      Asymmetric N-cadherin expression results in synapse dysfunction, synapse elimination, and axon retraction in cultured mouse neurons.
      PLoS One. 2013;8(1):e54105. doi: 10.1371/journal.pone.0054105.

    2012

    1. M.D. Lange, M. Doengi, J. Lesting, H.-C. Pape, K. Jüngling,
      A novel form of heterosynaptic long-term potentiation at interneuron-principal-neuron synapses in the amygdala requires nitric oxide signalling.
      J. Physiol. 590, 131-143 (2012).
    2. F. Chauveau, M.D. Lange, K. Jüngling, J. Lesting, T. Seidenbecher, H.C. Pape,
      Prevention of stress-impaired fear extinction through neuropeptide S action in the lateral amygdala.
      Neuropsychopharmacology, in press (2012).
    3. K. Jüngling, X. Liu, J. Lesting, P. Coulon, L. Sosulina, R.K. Reinscheid & H.-C. Pape,
      Activation of neuropeptide S expressing neurons in the locus coeruleus by corticotropin-releasing factor.
      J. Physiol., in press (2012).

    2011

    1. Fiederling A., Ewert R., Andreyeva A., Jüngling K., Gottmann K.
      E-cadherin is required at GABAergic synapses in cultured cortical neurons.
      Neurosci Lett. 2011 Jul 18. [Epub ahead of print]
    2. Okamura N., Garau C., Duangdao D.M., Clark S.D., Jüngling K., Pape H.-C. & Reinscheid R.K.
      Neuropeptide S Enhances Memory During the Consolidation Phase and Interacts with Noradrenergic Systems in the Brain.
      Neuropsychopharmacology 36: 744-752 (2011).

    2010

    1. Pape H.-C., Jüngling K., Seidenbecher T., Lesting J. &  Reinscheid R.K.
      Neuropeptide S: A transmitter system in the brain regulating fear and anxiety.
      Neuropharmacol. 58: 29-34 (2010)

    2008

    1. Jüngling K, Seidenbecher T, Sosulina L, Lesting J, Sangha S, Clark S, Okamura N, Duangdao D, Xu Y-L, Reinscheid R and Pape H-C
      Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala.
      Neuron 2008, 59: 293-310.

    2006

    1. Jüngling K, Eulenburg V, Moore R, Kemler R, Lessmann V and Gottmann K
      N-Cadherin transsynaptically regulates short-term plasticity at glutamatergic synapses in ES cellderived neurons.
      J. Neurosci. 2006, 26(26): 6968-6978.
    2. Walz C, Jüngling K, Lessmann V and Gottmann K
      Presynaptic plasticity in an immature neocortical network requires NMDA receptor activation and BDNF release.
      J Neurophysiol. 2006 Dec;96(6):3512-6.

    2005

    1. Copi A, Jüngling K and Gottmann K.
      Activity- and BDNF-Induced Plasticity of Miniture Synaptic Currents in ES Cell-Derived Neurons Integrated in a Neocortical Network.
      J.Neurophysiol. 94: 4538-43, 2005.

    2003

    1. Jüngling K, Nägler K, Pfrieger FW, Gottmann K.
      Purification of embryonic stem cell-derived neurons by immunoisolation.
      FASEB J. 2003 Nov;17(14):2100-2. Epub 2003 Sep 18.