Publikationen 2017

  • Wistuba J, Werler S, Lewejohann L, Brand C, Damm OS. Mouse models for the exploration of Klinefelter´s syndrome. In Conn MJ (ed) Animal models for the study of human diseases; 2nd revised edition, Elsevier Academic press, 2017, in press

  • Wistuba J, Brand C, Zitzmann M, Damm OS. Genetics of Klinefelter Syndrome: Experimental exploration. Monographs in Human Genetics, In Vogt PH (ed) Genetics of Male and Female Infertility, Karger, 2017, in press

  • Matschke V, Piccini I, Schubert J, Wrobel E, Lang F, Matschke J, Amedonu E, Meuth SG, Strünker T, Strutz-Seebohm N, Greber B, Scherkenbeck J & Seebohm G. (2017) "The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels" Cell Physiol Biochem. 40(6), 1549-1558. https://www.ncbi.nlm.nih.gov/pubmed/?term=27997884

  • Gromoll J, Weinbauer GF, Skaletsky H, Schlatt S, Rocchietti-March M, Page DC, Nieschlag E. The Old World monkey DAZ (Deleted in AZoospermia) gene yields insights into the evolution of the DAZ gene cluster on the human Y chromosome. Hum Mol Genet. 1999 Oct;8(11):2017-24. https://www.ncbi.nlm.nih.gov/pubmed/?term=10484770

  • Berger TK, Fußhöller DM, Goodwin N, Bönigk W, Müller A, Dokani Khesroshahi N, Brenker C, Wachten D, Krause E, Kaupp UB, Strünker T. Post-translational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating. J Physiol. 2017 Mar 1;595(5):1533-1546. doi: 10.1113/JP273189. https://www.ncbi.nlm.nih.gov/pubmed/27859356

  • Kaupp UB, Strünker T. Signaling in Sperm: More Different than Similar. Trends Cell Biol. 2017 Feb;27(2):101-109. doi: 10.1016/j.tcb.2016.10.002. Review. https://www.ncbi.nlm.nih.gov/pubmed/27825709

  • Nieschlag E, Bouloux PG, Stegmann BJ, Shankar RR, Guan Y, Tzontcheva A, McCrary Sisk C, Behre HM. An open-label clinical trial to investigate the efficacy and safety of corifollitropin alfa combined with hCG in adult men with hypogonadotropic hypogonadism. Reprod Biol Endocrinol. 2017 Mar 7;15(1):17. doi: 10.1186/s12958-017-0232-y. https://www.ncbi.nlm.nih.gov/pubmed/28270212

  • Zitzmann M, Rohayem J, Raidt J, Kliesch S, Kumar N, Sitruk-Ware R, Nieschlag E. Impact of various progestins with or without transdermal testosterone on gonadotropin levels for non-invasive hormonal male contraception: a randomized clinical trial. Andrology. 2017 Feb 11. doi: 10.1111/andr.12328. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/28189123

  • Rohayem J, Luberto A, Nieschlag E, Zitzmann M, Kliesch S. Delayed treatment of undescended testes may promote hypogonadism and infertility. Endocrine. 2017 Mar;55(3):914-924. doi: 10.1007/s12020-016-1178-0. https://www.ncbi.nlm.nih.gov/pubmed/28070708

  • Rohayem J, Hauffa BP, Zacharin M, Kliesch S, Zitzmann M; “German Adolescent Hypogonadotropic Hypogonadism Study Group”. Testicular growth and spermatogenesis: new goals for pubertal hormone replacement in boys with hypogonadotropic hypogonadism? -a multicentre prospective study of hCG/rFSH treatment outcomes during adolescence. Clin Endocrinol (Oxf). 2017 Jan;86(1):75-87. doi: 10.1111/cen.13164. https://www.ncbi.nlm.nih.gov/pubmed/27467188

  • Tröndle I, Westernströer B, Wistuba J, Terwort N, Schlatt S, Neuhaus N. Irradiation affects germ and somatic cells in prepubertal monkey testis xenografts. Mol Hum Reprod. 2017 Jan 27. doi: 10.1093/molehr/gax003. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/28130393

  • Neuhaus N, Yoon J, Terwort N, Kliesch S, Seggewiss J, Huge A, Voss R, Schlatt S, Grindberg RV, Schöler HR. Single-cell gene expression analysis reveals diversity among human spermatogonia. Mol Hum Reprod. 2017 Jan 15. doi: 10.1093/molehr/gaw079. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/28093458

  • Zitzmann M, Rohayem J, Raidt J, Kliesch S, Kumar N, Sitruk-Ware R, Nieschlag E. Impact of various progestins with or without transdermal testosterone on gonadotropin levels for non-invasive hormonal male contraception: a randomized clinical trial. Andrology. 2017 Feb 11. doi: 10.1111/andr.12328. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/28189123

  • Hentrich A, Wolter M, Szardening-Kirchner C, Lüers GH, Bergmann M, Kliesch S, Konrad L. Reduced numbers of Sertoli, germ, and spermatogonial stem cells in impaired spermatogenesis. Mod Pathol. 2017 Feb;30(2):311. doi: 10.1038/modpathol.2016.194. No abstract available. https://www.ncbi.nlm.nih.gov/pubmed/28144033

Publikationen 2016

  • Langenstroth-Röwer D, Gromoll J, Wistuba J, Tröndle I, Laurentino S, Schlatt S, Neuhaus N. De novo methylation in male germ cells of the common marmoset monkey occurs during postnatal development and is maintained in vitro. Epigenetics (2016) 27:0. [Epub ahead of print]

  • Rohayem J, Sinthofen N, Nieschlag E, Kliesch S, Zitzmann M. Causes of hypogonadotropic hypogonadism predict response to gonadotropin substitution in adults. Andrology. 2016 Jan;4(1):87-94

  • Laurentino SS, Borgmann J, Gromoll J. On the origin of sperm epigenetic heterogeneity. Reproduction. 2016 Feb 16. pii: REP-15-0436. [Epub ahead of print]

  • Pohl E, Gromoll J, Kliesch S, Wistuba J. An alternative interpretation of cellular 'selfish spermatogonial selection'- clusters in the human testis indicates the need for 3-D-analyses. Andrology. 2016 Mar;4(2):213-7.
  • Nieschlag E, Ferlin A, Gravholt CH, Gromoll J, Köhler B, Lejeune H, Rogol AD, Wistuba J. The Klinefelter syndrome: current management and research challenges. Andrology. 2016 May;4(3):545-9.

  • Schell C, Kretz O, Liang W, Kiefer B, Schneider S, Sellung D, Bork T, Leiber C, Rüegg MA,Mallidis C, Schlatt S, Mayerhofer A, Huber TB, Grahammer F. The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin IsEssential to Maintain Male Fertility. Am J Pathol. 2016 Feb;186(2):324-36.

  • Irfan S, Ehmcke J, Shahab M, Wistuba J, Schlatt S. Immunocytochemical localization of kisspeptin and kisspeptin receptor in the primate testis. J Med Primatol. 2016 Jun;45(3):105-11.

  • Klaus ES1, Gonzalez NH1, Bergmann M2, Bartkuhn M3, Weidner W4, Kliesch S5, Rathke C6. Murine and Human Spermatids Are Characterized by Numerous, Newly Synthesized and Differentially Expressed Transcription Factors and Bromodomain-Containing Proteins. Biol Reprod. 2016 Jul;95(1):4

  • Groeben C1, Baunacke M1, Borkowetz A1, Kliesch S2, Wülfing C3, Ihrig A4, Huber J5. [Decision aids for patients are widely accepted by German urologists : A survey among members of the German Society of Urology (DGU) and the Federation of German Urologists (BDU)]. Urologe A. 2016 Jun;55(6):784-91.

  • Schlatt S1, Ehmcke J2, Wistuba J3. [Cell biology and physiology of male reproduction]. Urologe A. 2016 Jul;55(7):868-76.

  • Corona G1, Giagulli VA2, Maseroli E3, Vignozzi L3, Aversa A4,5, Zitzmann M6, Saad F7,8,  Mannucci E9,Maggi M10. Testosterone supplementation and body composition: results from a meta-analysis of observational studies. J Endocrinol Invest. 2016 May 30.

  • Mukherjee S1, Jansen V2, Jikeli JF2, Hamzeh H2, Alvarez L1, Dombrowski M2, Balbach M1, Strünker T1,3, Seifert R1, Kaupp UB1, Wachten D2. A novel biosensor to study cAMP dynamics in cilia and flagella. Elife. 2016 Mar 22;5. pii: e14052.

  • Dean J1, Maggi M2, de Boer BJ3, Hellstrom W4, Khera M5, Kim ED6, McCullough A7, Wu F8, Zitzmann M9. Diagnosing secondary hypogonadism: important consequences forfertility and reversibility. BJU Int. 2016 Apr;117(4):552-4.

  • Corona G, Giagulli VA1, Maseroli E1, Vignozzi L1, Aversa A1, Zitzmann M1, Saad F2, Mannucci E1,Maggi M3. THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study. Eur J Endocrinol. 2016 Mar;174(3):R99-116.

  • Kliesch S1. [Androprotect and prospects for fertility treatment]. Urologe A. 2016 Jul;55(7):898-903.

  • Baunacke M1, Groeben C1, Borgmann H2, Schneider A3, Kliesch S4, Huber J5. [Evaluation of the joint information platform : Information offered by German urologists]. Urologe A. 2016 Jul;55(7):923-32.

  • Rohayem J1, Hauffa BP2, Zacharin M3, Kliesch S1, Zitzmann M1. Testicular growth and spermatogenesis: new goals for pubertal hormone replacement in boys with hypogonadotrophic hypogonadism? A multicentre prospective study of hCG/rFSH treatment outcomes during adolescence. Clin Endocrinol (Oxf). 2016 Jul 28.

  • Rohayem J1, Drechsel H, Tittel B, Hahn G, Pfaeffle R, Huebner A. Long-Term Outcomes, Genetics, and Pituitary Morphology in Patients with Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiencies: A Single-Centre Experience of Four Decades of Growth Hormone Replacement. Horm Res Paediatr. 2016 Aug 3.

  • Escada-Rebelo S1, Silva AF1, Amaral S1,2, Tavares RS1,2, Paiva C2,3, Schlatt S4, Ramalho-Santos J1,5, Mota PC1,2. Spermatogonial stem cell organization in felid testis as revealed by Dolichos biflorus lectin. Andrology. 2016 Jun 17.

  • Wu F1, Zitzmann M2, Heiselman D3, Donatucci C3, Knorr J3, Patel AB3, Kinchen K3. Demographic and Clinical Correlates of Patient-Reported Improvement in Sex Drive, Erectile Function, and Energy With Testosterone Solution 2. J Sex Med. 2016 Aug;13(8):1212-9.

  • Hartmann K1, Bennien J2, Wapelhorst B1, Bakhaus K2, Schumacher V3,4, Kliesch S5, Weidner W6, Bergmann M1, Geyer J2, Fietz D7. Current insights into the sulfatase pathway in human testis and cultured Sertoli cells. Histochem Cell Biol. 2016 Dec;146(6):737-748.

  • Rohayem J1, Drechsel H, Tittel B, Hahn G, Pfaeffle R, Huebner A. Long-Term Outcomes, Genetics, and Pituitary Morphology in Patients with Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiencies: A Single-Centre Experience of Four Decades of Growth Hormone Replacement. Horm Res Paediatr. 2016 Aug 3.

  • Escada-Rebelo S1, Silva AF1, Amaral S1,2, Tavares RS1,2, Paiva C2,3, Schlatt S4, Ramalho-Santos J1,5, Mota PC1,2. Spermatogonial stem cell organization in felid testis as revealed by Dolichos biflorus lectin. Andrology. 2016 Jun 17.

  • Hartmann K1, Bennien J2, Wapelhorst B1, Bakhaus K2, Schumacher V3,4, Kliesch S5, Weidner W6, Bergmann M1, Geyer J2, Fietz D7. Current insights into the sulfatase pathway in human testis and cultured Sertoli cells. Histochem Cell Biol. 2016 Dec;146(6):737-748.

  • Rohayem J1, Nieschlag E2, Zitzmann M2, Kliesch S2. Testicular function during puberty and young adulthood in patients with Klinefelter's syndrome with and without spermatozoa in seminal fluid. Andrology. 2016 Sep 9.

  • Berger TK1, Fußhöller DM1, Goodwin N1, Bönigk W1, Müller A1, Khesroshahi ND1, Brenker C1,2, Wachten D3, Krause E4, Kaupp UB1, Strünker T1,2. Posttranslational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating. J Physiol. 2016 Nov 17

  • Burg MC1, Lunkenheimer P2, Niederer P3, Brune C4, Redmann K5, Smerup M6, Spiegel U7, Becker F7, Maintz D1, Heindel W1, Anderson RH8. Pneumatic Distension of Ventricular Mural Architecture Validated Histologically. Rofo. 2016 Nov;188(11):1045-1053.

  • Le Gac S1, Nordhoff V2.Microfluidics for mammalian embryo culture and selection: where do we stand now? Mol Hum Reprod. 2016 Sep 27

Publikationen 2015

  • Yatsenko AN, Georgiadis AP, Röpke A, Berman AJ, Jaffe T, Olszewska M, Westernströer B, Sanfilippo J, Kurpisz M, Rajkovic A, et al. X-Linked TEX11 Mutations, Meiotic Arrest, and Azoospermia in Infertile Men. N Engl J Med 2015:1–11.
  • Zitzmann M, Bongers R, Werler S, Bogdanova N, Wistuba J, Kliesch S, Gromoll J, Tüttelmann F. Gene expression patterns in relation to the clinical phenotype in klinefelter syndrome. J Clin Endocrinol Metab 2015;100:E518–23.
  • Zitzmann M, Kliesch S. Erektile Dysfunktion beim Diabetiker. Aktuelle Urol 2015;46:303–308.
  • Westernströer B, Langenstroth D, Kliesch S, Troppmann B, Redmann K, Macdonald J, Mitchell R, Wistuba J, Schlatt S, Neuhaus N. Developmental expression patterns of chemokines CXCL11, CXCL12 and their receptor CXCR7 in testes of common marmoset and human. Cell Tissue Res 2015.
  • Schneider F, Redmann K, Wistuba J, Schlatt S, Kliesch S, Neuhaus N. Comparison of enzymatic digestion and mechanical dissociation of human testicular tissues. Fertil Steril 2015;104:302–311.e3.
  • Nordhoff V, Fricke RK, Schüring a. N, Zitzmann M, Kliesch S. Treatment strategies for severe oligoasthenoteratozoospermia (OAT) (<0.1 million/mL) patients. Andrology 2015:n/a–n/a.
  • Noelke J, Wistuba J, Damm OS, Fietz D, Gerber J, Gaehle M, Brehm R. A Sertoli cell-specific connexin43 knockout leads to altered interstitial connexin expression and increased Leydig cell numbers. Cell Tissue Res 2015.
  • Nieschlag E. Current topics in testosterone replacement of hypogonadal men. Best Pract Res Clin Endocrinol Metab 2015;29:77–90.
  • Laurentino S, Beygo J, Nordhoff V, Kliesch S, Wistuba J, Borgmann J, Buiting K, Horsthemke B, Gromoll J. Epigenetic germline mosaicism in infertile men. Hum Mol Genet 2015;24:1295–304.
  • Kläver R, Sánchez V, Damm OS, Redmann K, Lahrmann E, Sandhowe-Klaverkamp R, Rohde C, Wistuba J, Ehmcke J, Schlatt S, et al. Direct but no transgenerational effects of decitabine and vorinostat on male fertility. PLoS One 2015;10:e0117839.
  • Irfan S, Wistuba J, Ehmcke J, Shahab M, Schlatt S. Pubertal and testicular development in the common marmoset (Callithrix jacchus) shows high individual variation. Primate Biol 2015;2:1–8.
  • Haider A, Zitzmann M, Doros G, Isbarn H, Hammerer P, Yassin A. Incidence of prostate cancer in hypogonadal men receiving testosterone therapy: observations from 5-year median followup of 3 registries. J Urol 2015;193:80–6.
  • De Spiegelaere W, Dern-Wieloch J, Weigel R, Schumacher V, Schorle H, Nettersheim D, Bergmann M, Brehm R, Kliesch S, Vandekerckhove L, et al. Reference gene validation for RT-qPCR, a note on different available software packages. PLoS One 2015;10:e0122515.
  • Arnold SL, Kent T, Hogarth CA, Schlatt S, Prasad B, Haenisch M, Walsh T, Muller CH, Griswold MD, Amory JK, et al. Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations. J Lipid Res 2015;56:342–57.

Publikationen 2014

  • Nordhoff V. How to select immotile but viable spermatozoa on the day of intracytoplasmic sperm injection? An embryologist’s view. Andrology 2014;3:1–7.
  • Hemkemeyer SA, Schwarzer C, Boiani M, Ehmcke J, Le Gac S, Schlatt S, Nordhoff V. Effects of embryo culture media do not persist after implantation: a histological study in mice. Hum Reprod 2014;29:220–33.
  • Zengerling F, Hartmann M, Heidenreich A, Krege S, Albers P, Karl A, Weissbach L, Wagner W, Bedke J, Retz M, et al. German second-opinion network for testicular cancer: sealing the leaky pipe between evidence and clinical practice. Oncol Rep 2014;31:2477–81.
  • Windschüttl S, Nettersheim D, Schlatt S, Huber A, Welter H, Schwarzer JU, Köhn FM, Schorle H, Mayerhofer A. Are testicular mast cells involved in the regulation of germ cells in man? Andrology 2014;2:615–22.
  • Westernströer B, Terwort N, Ehmcke J, Wistuba J, Schlatt S, Neuhaus N. Profiling of Cxcl12 receptors, Cxcr4 and Cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for Cxcr7 in controlling Cxcl12 activity. PLoS One 2014;9:e112598.
  • Werler S, Wistuba J. A possible means of countering the underdiagnosis of Klinefelter Syndrome. Asian J Androl 2014;16:785.
  • Werler S, Demond H, Damm OS, Ehmcke J, Middendorff R, Gromoll J, Wistuba J. Germ cell loss is associated with fading Lin28a expression in a mouse model for Klinefelter’s syndrome. Reproduction 2014;147:253–64.
  • Tüttelmann F, Damm OS, Luetjens CM, Baldi M, Zitzmann M, Kliesch S, Nieschlag E, Gromoll J, Wistuba J, Simoni M. Intratesticular testosterone is increased in men with Klinefelter syndrome and may not be released into the bloodstream owing to altered testicular vascularization– a preliminary report. Andrology 2014;2:275–81.
  • Troppmann B, Kossack N, Nordhoff V, Schüring a N, Gromoll J. MicroRNA miR-513a-3p acts as a co-regulator of luteinizing hormone/chorionic gonadotropin receptor gene expression in human granulosa cells. Mol Cell Endocrinol 2014;390:65–72.
  • Traish AM, Guay AT, Zitzmann M. 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis. Horm Mol Biol Clin Investig 2014;20:73–80.
  • Tewes A-C, Ledig S, Tüttelmann F, Kliesch S, Wieacker P. DMRT1 mutations are rarely associated with male infertility. Fertil Steril 2014;102:816–820.e3.
  • Schlatt S, Ehmcke J. Regulation of spermatogenesis: an evolutionary biologist’s perspective. Semin Cell Dev Biol 2014;29:2–16.
  • Rohayem J, Tüttelmann F, Mallidis C, Nieschlag E, Kliesch S, Zitzmann M. Restoration of fertility by gonadotropin replacement in a man with hypogonadotropic azoospermia and testicular adrenal rest tumors due to untreated simple virilizing congenital adrenal hyperplasia. Eur J Endocrinol 2014;170:K11–7.
  • Rohayem J. Prophylaxe durch Aufklärung. Aktuel Urol 2014:257–258.
  • Richardson ME, Bleiziffer A, Tüttelmann F, Gromoll J, Wilkinson MF. Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility. Hum Mol Genet 2014;23:12–23.
  • Reuter K, Ehmcke J, Stukenborg J-B, Simoni M, Damm OS, Redmann K, Schlatt S, Wistuba J. Reassembly of somatic cells and testicular organogenesis in vitro. Tissue Cell 2014;46:86–96.
  • Ramm S a, Schärer L, Ehmcke J, Wistuba J. Sperm competition and the evolution of spermatogenesis. Mol Hum Reprod 2014;20:1169–79.
  • Paradowska-Dogan A, Fernandez A, Bergmann M, Kretzer K, Mallidis C, Vieweg M, Waliszewski P, Zitzmann M, Weidner W, Steger K, et al. Protamine mRNA ratio in stallion spermatozoa correlates with mare fecundity. Andrology 2014;2:521–30.
  • Nieschlag E, Werler S, Wistuba J, Zitzmann M. New approaches to the Klinefelter syndrome. Ann Endocrinol (Paris) 2014;75:88–97.
  • Nieschlag E, Nieschlag S. Testosterone deficiency: a historical perspective. Asian J Androl 2014;16:161–8.
  • Morgentaler A, Khera M, Maggi M, Zitzmann M. Commentary: Who is a candidate for testosterone therapy? A synthesis of international expert opinions. J Sex Med 2014;11:1636–45.
  • Langenstroth D, Kossack N, Westernströer B, Wistuba J, Behr R, Gromoll J, Schlatt S. Separation of somatic and germ cells is required to establish primate spermatogonial cultures. Hum Reprod 2014;29:2018–31.
  • Krausz C, Chianese C, Lo Giacco D, Tüttelmann F, Ferlin A, Ntostis P, Vinci S, Balercia G, Ars E, Ruiz-Castañé E, et al. Reply: Y-chromosome microdeletions are not associated with SHOX haploinsufficiency. Hum Reprod 2014;29:1114–5.
  • Kliesch S, Bongers R. Andrologie/Fertilität. In: Schmelz H-U, Leyh H (eds) Urologie. 2014, 163– 180.
  • Kliesch S. Infertilität. In: Schmelz, Sparwasser, Weidner (eds) Facharztwissen Urologie. 2014c, 559–584.
  • Kliesch S. [Hydrocele, spermatocele, and vasectomy: management of complications]. Urologe A 2014b;53:671–5.
  • Kliesch S. Diagnosis of Male Infertility: Diagnostic Work-up of the Infertile Man. Eur Urol Suppl 2014a;13:73–82.
  • Irfan S, Ehmcke J, Wahab F, Shahab M, Schlatt S. Intratesticular action of kisspeptin in rhesus monkey (Macaca mulatta). Andrologia 2014;46:610–7.
  • Grzesik P, Teichmann A, Furkert J, Rutz C, Wiesner B, Kleinau G, Schülein R, Gromoll J, Krause G. Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation. FEBS J 2014;281:1479–1492.
  • Gromoll J, Kläver R. Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives. Asian J Androl 2014;16:669.
  • Gierth M, Fritsche HM, Buchner H, May M, Aziz A, Otto W, Bolenz C, Trojan L, Hermann E, Tiemann A, et al. Clinical and pathological nodal staging score for urothelial carcinoma of the bladder: an external validation. World J Urol 2014;32:365–71.
  • Fietz D, Ratzenböck C, Hartmann K, Raabe O, Kliesch S, Weidner W, Klug J, Bergmann M. Expression pattern of estrogen receptors α and β and G-protein-coupled estrogen receptor 1 in the human testis. Histochem Cell Biol 2014;142:421–32.
  • Fereydouni B, Drummer C, Aeckerle N, Schlatt S, Behr R. The neonatal marmoset monkey ovary is very primitive exhibiting many oogonia. Reproduction 2014;148:237–47.
  • Busch AS, Tüttelmann F, Zitzmann M, Kliesch S, Gromoll J. The FSHB -211G>T variant attenuates serum FSH levels in the supraphysiological gonadotropin setting of Klinefelter syndrome. Eur J Hum Genet 2014:1–4.

Publikationen 2013

  • Mallidis C, Sanchez V, Wistuba J. Raman microspectroscopy: a method with great promise but which also needs circumspection. Hum Reprod 2013;28:2595–6.
  • Sánchez V, Wistuba J, Mallidis C. Semen analysis: update on clinical value, current needs and future perspectives. Reproduction 2013;146:R249–58.
  • Aponte P, Schlatt S, Franca L. Biotechnological approaches to the treatment of aspermatogenic men. Clinics 2013;68:157–167.
  • Zitzmann M, Behre HM, Kliesch S. Gonadotropin Treatment in Male Infertility. Reproduktionsmedizin und Endokrinol 2013;10:23–28.
  • Wistuba J, Luetjens CM, Ehmcke J, Redmann K, Damm OS, Steinhoff A, Sandhowe-Klaverkamp R, Nieschlag E, Simoni M, Schlatt S. Experimental endocrine manipulation by contraceptive regimen in the male marmoset (Callithrix jacchus). Reproduction 2013;145:439–51.
  • Troppmann B, Kleinau G, Krause G, Gromoll J. Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor. Hum Reprod Update 2013;19:583–602.
  • Siegeler K, Wistuba J, Damm OS, von Engelhardt N, Sachser N, Kaiser S. Early social instability affects plasma testosterone during adolescence but does not alter reproductive capacity or measures of stress later in life. Physiol Behav 2013;120:143–9.
  • Schüring AN, Busch AS, Bogdanova N, Gromoll J, Tüttelmann F. Effects of the FSH-β-subunit promoter polymorphism -211G->T on the hypothalamic-pituitary-ovarian axis in normally cycling women indicate a gender-specific regulation of gonadotropin secretion. J Clin Endocrinol Metab 2013;98:E82–6.
  • Röpke A, Stratis Y, Dossow-Scheele D, Wieacker P, Kliesch S, Tüttelmann F. Mosaicism for an unbalanced Y;21 translocation in an infertile man: a case report. J Assist Reprod Genet 2013;30:1553–8.
  • Reisman Y, Eardley I, Porst H. New developments in education and training in sexual medicine. J Sex Med 2013;10:918–23.
  • Reifschneider O, Wehe C a, Raj I, Ehmcke J, Ciarimboli G, Sperling M, Karst U. Quantitative bioimaging of platinum in polymer embedded mouse organs using laser ablation ICP-MS. Metallomics 2013;5:1440–7.
  • Pan F, Chi L, Schlatt S. Effects of nanostructures and mouse embryonic stem cells on in vitro morphogenesis of rat testicular cords. PLoS One 2013;8:e60054.
  • Nordhoff V, Schüring AN, Krallmann C, Zitzmann M, Schlatt S, Kiesel L, Kliesch S. Optimizing TESE-ICSI by laser-assisted selection of immotile spermatozoa and polarization microscopy for selection of oocytes. Andrology 2013;1:67–74.
  • Nieschlag E, Lerchl A. Sperm crisis: what crisis? Asian J Androl 2013;15:184–6.
  • Nieschlag E, Kumar N, Sitruk-Ware R. 7α-methyl-19-nortestosterone (MENTR): the population council’s contribution to research on male contraception and treatment of hypogonadism. Contraception 2013;87:288–95.
  • Nieschlag E. Hormonal male contraception: end of a dream or start of a new era? Endocrine 2013b;43:535–8.
  • Nieschlag E. Klinefelter syndrome: the commonest form of hypogonadism, but often overlooked or untreated. Dtsch Arztebl Int 2013a;110:347–53.
  • Mallidis C, Sanchez V, Wistuba J, Wuebbeling F, Burger M, Fallnich C, Schlatt S. Raman microspectroscopy: shining a new light on reproductive medicine. Hum Reprod Update 2013;20:403–14.
  • Lang T, Dechant M, Sanchez V, Wistuba J, Boiani M, Pilatz A, Stammler A, Middendorff R, Schuler G, Bhushan S, et al. Structural and functional integrity of spermatozoa is compromised as a consequence of acute uropathogenic E. coli-associated epididymitis. Biol Reprod 2013;89:59.
  • Kossack N, Troppmann B, Richter-Unruh A, Kleinau G, Gromoll J. Aberrant transcription of the LHCGR gene caused by a mutation in exon 6A leads to Leydig cell hypoplasia type II. Mol Cell Endocrinol 2013;366:59–67.
  • Kossack N, Terwort N, Wistuba J, Ehmcke J, Schlatt S, Schöler H, Kliesch S, Gromoll J. A combined approach facilitates the reliable detection of human spermatogonia in vitro. Hum Reprod 2013;28:3012–25.
  • Kläver R, Tüttelmann F, Bleiziffer A, Haaf T, Kliesch S, Gromoll J. DNA methylation in spermatozoa as a prospective marker in andrology. Andrology 2013;1:731–40.
  • Kanber D, Buiting K, Roos C, Gromoll J, Kaya S, Horsthemke B, Lohmann D. The origin of the RB1 imprint. PLoS One 2013;8:e81502.
  • Fietz D, Bakhaus K, Wapelhorst B, Grosser G, Günther S, Alber J, Döring B, Kliesch S, Weidner W, Galuska CE, et al. Membrane transporters for sulfated steroids in the human testis--cellular localization, expression pattern and functional analysis. PLoS One 2013;8:e62638.
  • Esteves TC, van Rossem F, Nordhoff V, Schlatt S, Boiani M, Le Gac S. A microfluidic system supports single mouse embryo culture leading to full-term development. RSC Adv 2013;3:26451.
  • Eppelmann U, Gottardo F, Wistuba J, Ehmcke J, Kossack N, Westernstroeer B, Redmann K, Wuebbeling F, Burger M, Tuettelmann F, et al. Raman microspectroscopic discrimination of TCam-2 cultures reveals the presence of two sub-populations of cells. Cell Tissue Res 2013;354:623–32.
  • Dieckmann K-P, Wilken S, Loy V, Matthies C, Kleinschmidt K, Bedke J, Martinschek A, Souchon R, Pichlmeier U, Kliesch S. Treatment of testicular intraepithelial neoplasia (intratubular germ cell neoplasia unspecified) with local radiotherapy or with platinum-based chemotherapy: a survey of the German Testicular Cancer Study Group. Ann Oncol 2013;24:1332–7.
  • Czeloth K, Kälble T, Kliesch S. [Varicocele in adolescents]. Urologe A 2013;52:48–53.
  • Chianese C, Lo Giacco D, Tüttelmann F, Ferlin A, Ntostis P, Vinci S, Balercia G, Ars E, Ruiz-Castañé E, Giglio S, et al. Y-chromosome microdeletions are not associated with SHOX haploinsufficiency. Hum Reprod 2013;28:3155–60.
  • Beyer J, Albers P, Altena R, Aparicio J, Bokemeyer C, Busch J, Cathomas R, Cavallin-Stahl E, Clarke NW, Claßen J, et al. Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer. Ann Oncol 2013;24:878–88.
  • Amaral S, Redmann K, Sanchez V, Mallidis C, Ramalho-Santos J, Schlatt S. UVB irradiation as a tool to assess ROS-induced damage in human spermatozoa. Andrology 2013;1:707–14.

Publikationen 2012

  • Rohayem J, Kliesch S. [Androgen deprivation therapy in prostate cancer. Indication and systemic consequences]. Urologe A 2012;51:557–64; quiz 565–6.
  • Ebert AK, Kliesch S, Neissner C, Reutter H, Rösch WH. Testicular tumors in patients with exstrophy-epispadias complex. J Urol 2012;188:1300–5.
  • Yeung C-H, Wang K, Cooper TG. Why are epididymal tumours so rare? Asian J Androl 2012;14:465–75.
  • Wistuba J, Nieschlag E, Semjonow A, Sandhowe-Klaverkamp R, Friderichs-Gromoll S, Zitzmann M, Simoni M, Luetjens CM. Testosterone-induced prostate growth is blocked by co- and preadministration of norethisterone enanthate in castrated cynomolgus monkeys. Urol Int 2012;88:358–64.
  • Von Schönfeldt V, Chandolia R, Ochsenkühn R, Nieschlag E, Kiesel L, Sonntag B. FSH prevents depletion of the resting follicle pool by promoting follicular number and morphology in fresh and cryopreserved primate ovarian tissues following xenografting. Reprod Biol Endocrinol 2012;10:98.
  • Tüttelmann F, Laan M, Grigorova M, Punab M, Sõber S, Gromoll J. Combined effects of the variants FSHB -211G>T and FSHR 2039A>G on male reproductive parameters. J Clin Endocrinol Metab 2012;97:3639–47.
  • Schwarzer C, Esteves TC, Araúzo-Bravo MJ, Le Gac S, Nordhoff V, Schlatt S, Boiani M. ART culture conditions change the probability of mouse embryo gestation through defined cellular and molecular responses. Hum Reprod 2012;27:2627–40.
  • Schüring AN, Welp A, Gromoll J, Zitzmann M, Sonntag B, Nieschlag E, Greb RR, Kiesel L. Role of the CAG repeat polymorphism of the androgen receptor gene in polycystic ovary syndrome (PCOS). Exp Clin Endocrinol Diabetes 2012;120:73–9.
  • Schlatt S, Kliesch S. Fertilitätsprotektion bei Männern. Gynäkologische Endokrinol 2012;10:91–97.
  • Sánchez V, Redmann K, Wistuba J, Wübbeling F, Burger M, Oldenhof H, Wolkers WF, Kliesch S, Schlatt S, Mallidis C. Oxidative DNA damage in human sperm can be detected by Raman microspectroscopy. Fertil Steril 2012;98:1124–9.e1–3.
  • Reuter K, Schlatt S, Ehmcke J, Wistuba J. Fact or fiction: In vitro spermatogenesis. Spermatogenesis 2012;2:245–252.
  • Pühse G, Kliesch S. Response to the Letter to the Editor from F. Sanguedolce. J Androl 2012.
  • Puhse G, Kliesch S. Response. J Androl 2012;33:896–896.
  • Pignatti E, Casarini L, Scaltriti S, Wistuba J, Schlatt S, Rossi A, Lachhab A, Taliani E, Carani C, Simoni M. Aromatase expression in human peripheral blood leucocytes (PBLs) and in various tissues in primates: studies in elderly humans and cynomolgus monkeys. J Med Primatol 2012;41:372–83.
  • Nettersheim D, Westernströer B, Haas N, Leinhaas A, Brüstle O, Schlatt S, Schorle H. Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells. Genes Chromosomes Cancer 2012;51:717–26.
  • Mota PC, Ehmcke J, Westernströer B, Gassei K, Ramalho-Santos J, Schlatt S. Effects of different storage protocols on cat testis tissue potential for xenografting and recovery of spermatogenesis. Theriogenology 2012;77:299–310.
  • Mohr M, Hartig I, Kessler T, Hamisch C, Kliesch S, Krug U, Spieker T, Semik M, Wiebe K, Pühse G, et al. High-dose chemotherapy with autologous PBSC transplantation for poor prognosis germ cell tumors: a retrospective monocenter analysis of 44 cases. Bone Marrow Transplant 2012;47:1321–5.
  • Mallidis C, Cooper TG, Hellenkemper B, Lablans M, Uckert F, Nieschlag E. Ten years’ experience with an external quality control program for semen analysis. Fertil Steril 2012;98:611–616.e4.
  • Kliesch S, Zitzmann M. Hypogonadismus des alternden Mannes. Der Priv 2012:14–17.
  • Kliesch S, Heidemann S, Schorpp F, Wörmann B. Klinefelter-Syndrom und Krebs. Reproduktionsmedizin und Endokrinol 2012;9:262–265.
  • Kläver R, Bleiziffer A, Redmann K, Mallidis C, Kliesch S, Gromoll J. Routine cryopreservation of spermatozoa is safe--evidence from the DNA methylation pattern of nine spermatozoa genes. J Assist Reprod Genet 2012;29:943–50.
  • Jahnukainen K, Ehmcke J, Nurmio M, Schlatt S. Autologous ectopic grafting of cryopreserved testicular tissue preserves the fertility of prepubescent monkeys that receive sterilizing cytotoxic therapy. Cancer Res 2012;72:5174–8.
  • Jacob J, Endepols S, Pelz H-J, Kampling E, Cooper TG, Yeung CH, Redmann K, Schlatt S. Vitamin K requirement and reproduction in bromadiolone-resistant Norway rats. Pest Manag Sci 2012;68:378–85.
  • Eildermann K, Gromoll J, Behr R. Misleading and reliable markers to differentiate between primate testis-derived multipotent stromal cells and spermatogonia in culture. Hum Reprod 2012;27:1754–67.
  • Eildermann K, Aeckerle N, Debowski K, Godmann M, Christiansen H, Heistermann M, Schweyer S, Bergmann M, Kliesch S, Gromoll J, et al. Developmental expression of the pluripotency factor sal-like protein 4 in the monkey, human and mouse testis: restriction to premeiotic germ cells. Cells Tissues Organs 2012;196:206–20.
  • Dieckmann K-P, Kliesch S, Schrader M, Krege S, Loy V. [Carcinoma in situ of the testis]. Pathologe 2012;33 Suppl 2:376–7; author reply 378.
  • Cooper TG. Comment on the morphology of spermatozoa in air-dried seminal smears. Int J Androl 2012;35:105–6.
  • Albert S, Wistuba J, Eildermann K, Ehmcke J, Schlatt S, Gromoll J, Kossack N. Comparative marker analysis after isolation and culture of testicular cells from the immature marmoset. Cells Tissues Organs 2012;196:543–54.
  • Aeckerle N, Eildermann K, Drummer C, Ehmcke J, Schweyer S, Lerchl A, Bergmann M, Kliesch S, Gromoll J, Schlatt S, et al. The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells? Mol Hum Reprod 2012;18:477–88.
  • Abu Elhija M, Lunenfeld E, Schlatt S, Huleihel M. Differentiation of murine male germ cells to spermatozoa in a soft agar culture system. Asian J Androl 2012;14:285–93.

Publikationen 2011

  • Dieckmann K-P, Matthies C, Kliesch S. Carboplatin does not prevent contralateral testicular tumors in patients with seminoma. J Clin Oncol 2011;29:2944–5; author reply 2945–6.
  • Werler S, Poplinski A, Gromoll J, Wistuba J. Expression of selected genes escaping from X inactivation in the 41, XX(Y)* mouse model for Klinefelter’s syndrome. Acta Paediatr 2011;100:885–91.
  • Wang C, Jackson G, Jones TH, Matsumoto AM, Nehra A, Perelman MA, Swerdloff RS, Traish A, Zitzmann M, Cunningham G. Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes. Diabetes Care 2011;34:1669–75.
  • Von Schönfeldt V, Chandolia R, Kiesel L, Nieschlag E, Schlatt S, Sonntag B. Advanced follicle development in xenografted prepubertal ovarian tissue: the common marmoset as a nonhuman primate model for ovarian tissue transplantation. Fertil Steril 2011b;95:1428–34.
  • Von Schönfeldt V, Chandolia R, Kiesel L, Nieschlag E, Schlatt S, Sonntag B. Assessment of follicular development in cryopreserved primate ovarian tissue by xenografting: prepubertal tissues are less sensitive to the choice of cryoprotectant. Reproduction 2011a;141:481–90.
  • Volkmann J, Müller D, Feuerstacke C, Kliesch S, Bergmann M, Mühlfeld C, Middendorff R. Disturbed spermatogenesis associated with thickened lamina propria of seminiferous tubules is not caused by dedifferentiation of myofibroblasts. Hum Reprod 2011;26:1450–61.
  • Tüttelmann F, Simoni M, Kliesch S, Ledig S, Dworniczak B, Wieacker P, Röpke A. Copy number variants in patients with severe oligozoospermia and Sertoli-cell-only syndrome. PLoS One 2011;6:e19426.
  • Tüttelmann F, Werny F, Cooper TG, Kliesch S, Simoni M, Nieschlag E. Clinical experience with azoospermia: aetiology and chances for spermatozoa detection upon biopsy. Int J Androl 2011;34:291–8.
  • Traish AM, Miner MM, Morgentaler A, Zitzmann M. Testosterone deficiency. Am J Med 2011;124:578–87.
  • Traish AM, Hassani J, Guay AT, Zitzmann M, Hansen ML. Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients. J Sex Med 2011;8:872–84.
  • Steilmann C, Paradowska A, Bartkuhn M, Vieweg M, Schuppe H-C, Bergmann M, Kliesch S, Weidner W, Steger K. Presence of histone H3 acetylated at lysine 9 in male germ cells and its distribution pattern in the genome of human spermatozoa. Reprod Fertil Dev 2011;23:997–1011.
  • Sinha SK, Bhangoo A, Ten S, Gromoll J. Leydig cell hypoplasia due to inactivating luteinizing hormone/chorionic gonadotropin receptor gene mutation presenting as a 46,XY DSD. Adv Exp Med Biol 2011;707:147–8.
  • Schüring AN, Nordhoff V, Schulte N, Kliesch S, Kiesel L, Berdel WE, Wessling J, Koschmieder S. Spontaneous conception and live birth after gonadotoxic chemotherapy for an aggressive bilateral ovarian Burkitt’s lymphoma. Eur J Obstet Gynecol Reprod Biol 2011;158:362–4.
  • Schneider G, Nienhaus K, Gromoll J, Heuft G, Nieschlag E, Zitzmann M. Sex hormone levels, genetic androgen receptor polymorphism, and anxiety in ≥50-year-old males. J Sex Med 2011b;8:3452–64.
  • Schneider G, Nienhaus K, Gromoll J, Heuft G, Nieschlag E, Zitzmann M. Depressive symptoms in men aged 50 years and older and their relationship to genetic androgen receptor polymorphism and sex hormone levels in three different samples. Am J Geriatr Psychiatry 2011a;19:274–83.
  • Saad F, Aversa A, Isidori AM, Zafalon L, Zitzmann M, Gooren L. Onset of effects of testosterone treatment and time span until maximum effects are achieved. Eur J Endocrinol 2011;165:675–85.
  • Rohayem J, Ehlers C, Wiedemann B, Holl R, Oexle K, Kordonouri O, Salzano G, Meissner T, Burger W, Schober E, et al. Diabetes and neurodegeneration in Wolfram syndrome: a multicenter study of phenotype and genotype. Diabetes Care 2011;34:1503–10.
  • Pühse G, Wachsmuth JU, Kemper S, Husstedt IW, Evers S, Kliesch S. Chronic pain has a negative impact on sexuality in testis cancer survivors. J Androl 2011;33:886–93.
  • Pühse G, Hense J, Bergmann M, Kliesch S. Bilateral histological evaluation of exocrine testicular function in men with obstructive azoospermia: condition of spermatogenesis and andrological implications? Hum Reprod 2011;26:2606–12.
  • Pühse G, Secker A, Kemper S, Hertle L, Kliesch S. Testosterone deficiency in testicular germ-cell cancer patients is not influenced by oncological treatment. Int J Androl 2011;34:e351–7.
  • Nordhoff V, Sonntag B, von Tils D, Götte M, Schüring AN, Gromoll J, Redmann K, Casarini L, Simoni M. Effects of the FSH receptor gene polymorphism p.N680S on cAMP and steroid production in cultured primary human granulosa cells. Reprod Biomed Online 2011;23:196–203.
  • Nieschlag E, Vorona E, Wenk M, Hemker A-K, Kamischke A, Zitzmann M. Hormonal male contraception in men with normal and subnormal semen parameters. Int J Androl 2011;34:556–67.
  • Nieschlag E. The struggle for male hormonal contraception. Best Pract Res Clin Endocrinol Metab 2011;25:369–75.
  • Müller T, Hupfeld T, Roessler J, Simoni M, Gromoll J, Behr R. Molecular cloning and functional characterization of endogenous recombinant common marmoset monkey (Callithrix jacchus) follicle-stimulating hormone. J Med Primatol 2011;40:111–9.
  • Mulholland J, Mallidis C, Agbaje I, McClure N. Male diabetes mellitus and assisted reproduction treatment outcome. Reprod Biomed Online 2011;22:215–9.
  • Mallidis C, Wistuba J, Bleisteiner B, Damm OS, Gross P, Wübbeling F, Fallnich C, Burger M, Schlatt S. In situ visualization of damaged DNA in human sperm by Raman microspectroscopy. Hum Reprod 2011;26:1641–9.
  • Mallidis C, Czerwiec A, Filippi S, O’Neill J, Maggi M, McClure N. Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism. Reproduction 2011;142:63–71.
  • Mallidis C, Agbaje I, McClure N, Kliesch S. [The influence of diabetes mellitus on male reproductive function: a poorly investigated aspect of male infertility]. Urologe A 2011;50:33–7.
  • Lüpold S, Wistuba J, Damm OS, Rivers JW, Birkhead TR. Sperm competition leads to functional adaptations in avian testes to maximize sperm quantity and quality. Reproduction 2011;141:595–605.
  • Kozina V, Cappallo-Obermann H, Gromoll J, Spiess A-N. A one-step real-time multiplex PCR for screening Y-chromosomal microdeletions without downstream amplicon size analysis. PLoS One 2011;6:e23174.
  • Ko K, Reinhardt P, Tapia N, Schneider RK, Araúzo-Bravo MJ, Han DW, Greber B, Kim J, Kliesch S, Zenke M, et al. Brief report: evaluating the potential of putative pluripotent cells derived from human testis. Stem Cells 2011;29:1304–9.
  • Kliesch S, Zitzmann M, Behre HM. [Fertility in patients with Klinefelter syndrome (47,XXY)]. Urologe A 2011;50:26–32.
  • Kliesch S, Weidner W. [Removal of andrology from the specialty training programme in urology: a step forward or backward: initial assessment]. Urologe A 2011;50:952–7.
  • Kliesch S. Infertilität des Mannes. Gynäkologische Endokrinol 2011b;9:171–186.
  • Kliesch S. Varikozelen-Therapie bei männlicher Infertilität. Aktuel Urol 2011a;42:303–305.
  • Jaroszynski L, Zimmer J, Fietz D, Bergmann M, Kliesch S, Vogt PH. Translational control of the AZFa gene DDX3Y by 5’UTR exon-T extension. Int J Androl 2011;34:313–26.
  • Jahnukainen K, Ehmcke J, Quader M a, Saiful Huq M, Epperly MW, Hergenrother S, Nurmio M, Schlatt S. Testicular recovery after irradiation differs in prepubertal and pubertal non-human primates, and can be enhanced by autologous germ cell transplantation. Hum Reprod 2011;26:1945–54.
  • Jahnukainen K, Ehmcke J, Hou M, Schlatt S. Testicular function and fertility preservation in male cancer patients. Best Pract Res Clin Endocrinol Metab 2011;25:287–302.
  • Honaramooz A, Schlatt S, Orwig K, Kim N-H. Recent advances in reproductive technologies. Vet Med Int 2011;2011:915031.
  • Hentrich A, Wolter M, Szardening-Kirchner C, Lüers GH, Bergmann M, Kliesch S, Konrad L. Reduced numbers of Sertoli, germ, and spermatogonial stem cells in impaired spermatogenesis. Mod Pathol 2011;24:1380–9.
  • Gottardo F, Kliesch S. [Semen analysis: spermiogram according to WHO 2010 criteria]. Urologe A 2011b;50:101–8.
  • Gottardo F, Kliesch S. PDE-5-Inhibitoren verbessern Spermienqualität Medikamentöse. Aktuel Urol 2011a:220 – 221.
  • Fijak M, Schneider E, Klug J, Bhushan S, Hackstein H, Schuler G, Wygrecka M, Gromoll J, Meinhardt A. Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: evidence for a direct role of testosterone on regulatory T cell expansion. J Immunol 2011;186:5162–72.
  • Fietz D, Geyer J, Kliesch S, Gromoll J, Bergmann M. Evaluation of CAG repeat length of androgen receptor expressing cells in human testes showing different pictures of spermatogenic impairment. Histochem Cell Biol 2011;136:689–97.
  • El Hajj N, Zechner U, Schneider E, Tresch A, Gromoll J, Hahn T, Schorsch M, Haaf T. Methylation status of imprinted genes and repetitive elements in sperm DNA from infertile males. Sex Dev 2011;5:60–9.
  • Ehmcke J, Gassei K, Westernströer B, Schlatt S. Immature rhesus monkey (Macaca mulatta) testis xenografts show increased growth, but not enhanced seminiferous differentiation, under human chorionic gonadotropin treatment of nude mouse recipients. Int J Androl 2011;34:e459–67.
  • Del Priore G, Schlatt S, Wagner R, Reynoso E, Malanowska-Stega J. Uterus transplantation: on the edge. Semin Reprod Med 2011;29:55–60.
  • Cooper TG. The epididymis, cytoplasmic droplets and male fertility. Asian J Androl 2011;13:130–8.
  • Cavalcanti MCO, Steilmann C, Failing K, Bergmann M, Kliesch S, Weidner W, Steger K. Apoptotic gene expression in potentially fertile and subfertile men. Mol Hum Reprod 2011;17:415–20.
  • Bunk EC, Stelzer S, Hermann S, Schäfers M, Schlatt S, Schwamborn JC. Cellular organization of adult neurogenesis in the Common Marmoset. Aging Cell 2011;10:28–38.
  • Albers P, Algaba F, Cohn-Cedermark G, DeSantis M, Kliesch S, Moul JW. Diagnosis, staging, and risk factors: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009. Urology 2011;78:S427–34.
  • Adiga SK, Ehmcke J, Schlatt S, Kliesch S, Westernströer B, Luetjens CM, Wistuba J, Gromoll J. Reduced expression of DNMT3B in the germ cells of patients with bilateral spermatogenic arrest does not lead to changes in the global methylation status. Mol Hum Reprod 2011;17:545–9.
  • Adams C, Henke A, Gromoll J. A novel two-promoter-one-gene system of the chorionic gonadotropin β gene enables tissue-specific expression. J Mol Endocrinol 2011;47:285–98.

Publikationen 2010

  • Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HWG, Behre HM, Haugen TB, Kruger T, Wang C, Mbizvo MT, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010;16:231–45.
  • Zitzmann M. Testosterone deficiency and treatment in older men: definition, treatment, pitfalls. Asian J Androl 2010b;12:623–5.
  • Zitzmann M. [Hormonal contraception for men: still a current issue]. Urologe A 2010a;49:16–9.
  • Yeung C-H. Aquaporins in spermatozoa and testicular germ cells: identification and potential role. Asian J Androl 2010;12:490–9.
  • Yeung CH, Cooper TG. 035- Aquaporin AQP11 in the testis: molecular identity and association with the processing of residual cytoplasm of elongated spermatids. Reproduction 2010;139:209–16.
  • Yeung CH, Callies C, Tüttelmann F, Kliesch S, Cooper TG. Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance. Int J Androl 2010;33:629–41.
  • Wistuba J, Luetjens CM, Stukenborg J-B, Poplinski A, Werler S, Dittmann M, Damm OS, Hämäläinen T, Simoni M, Gromoll J. Male 41, XXY* mice as a model for klinefelter syndrome: hyperactivation of leydig cells. Endocrinology 2010;151:2898–910.
  • Wistuba J. Animal models for Klinefelter’s syndrome and their relevance for the clinic. Mol Hum Reprod 2010;16:375–85.
  • Welzel M, Schwarz H-P, Hedderich J, Dörr HG, Binder G, Brämswig JH, Krude H, Richter-Unruh A, Niedziela M, Gromoll J, et al. No correlation between androgen receptor CAG and GGN repeat length and the degree of genital virilization in females with 21-hydroxylase deficiency. J Clin Endocrinol Metab 2010;95:2443–50.
  • Tüttelmann F, Krenková P, Römer S, Nestorovic a R, Ljujic M, Stambergová A, Macek M, Nieschlag E, Gromoll J, Simoni M. A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts. Int J Androl 2010;33:e240–8.
  • Tüttelmann F, Gromoll J. Novel genetic aspects of Klinefelter’s syndrome. Mol Hum Reprod 2010;16:386–95.
  • Te Velde E, Burdorf A, Nieschlag E, Eijkemans R, Kremer JAM, Roeleveld N, Habbema D. Is human fecundity declining in Western countries? Hum Reprod 2010;25:1348–53.
  • Steilmann C, Cavalcanti MCO, Bergmann M, Kliesch S, Weidner W, Steger K. Aberrant mRNA expression of chromatin remodelling factors in round spermatid maturation arrest compared with normal human spermatogenesis. Mol Hum Reprod 2010;16:726–33.
  • Schneider G, Nienhaus K, Gromoll J, Heuft G, Nieschlag E, Zitzmann M. Aging males’ symptoms in relation to the genetically determined androgen receptor CAG polymorphism, sex hormone levels and sample membership. Psychoneuroendocrinology 2010;35:578–87.
  • Schlatt S, Westernströer B, Gassei K, Ehmcke J. Donor-host involvement in immature rat testis xenografting into nude mouse hosts. Biol Reprod 2010;82:888–95.
  • Schlatt S, Hillier SG, Foresta C. Klinefelter’s syndrome: from chromosome to clinic. Mol Hum Reprod 2010;16:373–4.
  • Schlatt S, Gassei K, Westernströer B, Ehmcke J. Modulating testicular mass in xenografting: a model to explore testis development and endocrine function. Endocrinology 2010;151:4018–23.
  • Sartorius G a, Nieschlag E. Paternal age and reproduction. Hum Reprod Update 2010;16:65–79.
  • Pühse G, Wachsmuth JU, Kemper S, Husstedt IW, Kliesch S, Evers S. Phantom testis syndrome: prevalence, phenomenology and putative mechanisms. Int J Androl 2010;33:e216–20.
  • Poplinski A, Wieacker P, Kliesch S, Gromoll J. Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome. Eur J Endocrinol 2010;162:169–75.
  • Poplinski a, Tüttelmann F, Kanber D, Horsthemke B, Gromoll J. Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2/H19 ICR1. Int J Androl 2010;33:642–9.
  • O’Neill J, Czerwiec A, Agbaje I, Glenn J, Stitt A, McClure N, Mallidis C. Differences in mouse models of diabetes mellitus in studies of male reproduction. Int J Androl 2010;33:709–16.
  • Nieschlag E. Clinical trials in male hormonal contraception. Contraception 2010b;82:457–70.
  • Nieschlag E. Male hormonal contraception. Handb Exp Pharmacol 2010a:197–223.
  • Mota PC, Ramalho-Santos J, Schlatt S. Xenografting as a tool to preserve endangered species: outcomes and challenges in model systems. Vet Med Int 2010;2011.
  • Kuechler A, Hauffa BP, Köninger A, Kleinau G, Albrecht B, Horsthemke B, Gromoll J. An unbalanced translocation unmasks a recessive mutation in the follicle-stimulating hormone receptor (FSHR) gene and causes FSH resistance. Eur J Hum Genet 2010;18:656–61.
  • Ko K, Araúzo-Bravo MJ, Tapia N, Kim J, Lin Q, Bernemann C, Han DW, Gentile L, Reinhardt P, Greber B, et al. Human adult germline stem cells in question. Nature 2010;465:E1; discussion E3.
  • Kliesch S. [Continuing medical education in andrology : Continuing education between wish and reality]. Urologe A 2010;49:930–3.
  • Hinton BT, Cooper TG. The epididymis as a target for male contraceptive development. Handb Exp Pharmacol 2010:117–37.
  • Hellenkemper B, Ströse A, Cooper TG. Mountant-induced loss of Shorr-stained blue sperm tails. Asian J Androl 2010;12:278–80.
  • Handelsman DJ, Cooper TG. Foreword to Semen Analysis in 21st Century Medicine special issue in Asian Journal of Andrology. Asian J Androl 2010;12:7–10.
  • Gassei K, Ehmcke J, Dhir R, Schlatt S. Magnetic activated cell sorting allows isolation of spermatogonia from adult primate testes and reveals distinct GFRa1-positive subpopulations in men. J Med Primatol 2010;39:83–91.
  • Gassei K, Ehmcke J, Wood M a, Walker WH, Schlatt S. Immature rat seminiferous tubules reconstructed in vitro express markers of Sertoli cell maturation after xenografting into nude mouse hosts. Mol Hum Reprod 2010;16:97–110.
  • Flöel a, Ruscheweyh R, Krüger K, Willemer C, Winter B, Völker K, Lohmann H, Zitzmann M, Mooren F, Breitenstein C, et al. Physical activity and memory functions: are neurotrophins and cerebral gray matter volume the missing link? Neuroimage 2010;49:2756–63.
  • Damm OS, Cooper TG. Maturation of sperm volume regulation in the rat epididymis. Asian J Androl 2010;12:578–90.
  • Buvat J, Maggi M, Gooren L, Guay AT, Kaufman J, Morgentaler A, Schulman C, Tan HM, Torres LO, Yassin A, et al. Endocrine aspects of male sexual dysfunctions. J Sex Med 2010;7:1627–56.
  • Brune M, Adams C, Gromoll J. Primate FSH-receptor promoter nucleotide sequence heterogeneity affects FSH-receptor transcription. Mol Cell Endocrinol 2010;317:90–8.
  • Bellastella G, Cooper TG, Battaglia M, Ströse A, Torres I, Hellenkemper B, Soler C, Sinisi AA. Dimensions of human ejaculated spermatozoa in Papanicolaou-stained seminal and swim-up smears obtained from the Integrated Semen Analysis System (ISAS(®)). Asian J Androl 2010;12:871–9.
  • Albert S, Ehmcke J, Wistuba J, Eildermann K, Behr R, Schlatt S, Gromoll J. Germ cell dynamics in the testis of the postnatal common marmoset monkey (Callithrix jacchus). Reproduction 2010;140:733–42.

Publikationen 2009

  • Zitzmann M. Testosterone deficiency, insulin resistance and the metabolic syndrome. Nat Rev Endocrinol 2009b;5:673–81.
  • Zitzmann M. The role of the CAG repeat androgen receptor polymorphism in andrology. Front Horm Res 2009a;37:52–61.
  • Yeung C-H, Callies C, Rojek A, Nielsen S, Cooper TG. Aquaporin isoforms involved in physiological volume regulation of murine spermatozoa. Biol Reprod 2009;80:350–7.
  • Yeung CH, Tüttelmann F, Bergmann M, Nordhoff V, Vorona E, Cooper TG. Coiled sperm from infertile patients: characteristics, associated factors and biological implication. Hum Reprod 2009;24:1288–95.
  • Yeung CH, Beiglböck-Karau L, Luetjens CM, Wunsch A, Nieschlag E. Quantification of seminal germ cells in azoospermia: correlations with testicular histology and TESE outcome. Int J Androl 2009;32:242–54.
  • Widiasih D, Yeung C-H, Junaidi A, Cooper TG. Multistep and single-step treatment of human spermatozoa with cryoprotectants. Fertil Steril 2009;92:382–9.
  • Tüttelmann F, Dykstra N, Themmen APN, Visser JA, Nieschlag E, Simoni M. Anti-Müllerian hormone in men with normal and reduced sperm concentration and men with maldescended testes. Fertil Steril 2009;91:1812–9.
  • Stukenborg J-B, Schlatt S, Simoni M, Yeung C-H, Elhija MA, Luetjens CM, Huleihel M, Wistuba J. New horizons for in vitro spermatogenesis? An update on novel three-dimensional culture systems as tools for meiotic and post-meiotic differentiation of testicular germ cells. Mol Hum Reprod 2009;15:521–9.
  • Setyawan EEM, Cooper TG, Widiasih D a, Junaidi A, Yeung C-H. Effects of cryoprotectant treatments on bovine sperm function and osmolyte content. Asian J Androl 2009;11:571–81.
  • Schüring AN, Lutz F, Tüttelmann F, Gromoll J, Kiesel L, Götte M. Role of syndecan-3 polymorphisms in obesity and female hyperandrogenism. J Mol Med (Berl) 2009;87:1241–50.
  • Schlatt S, Ehmcke J, Jahnukainen K. Testicular stem cells for fertility preservation: preclinical studies on male germ cell transplantation and testicular grafting. Pediatr Blood Cancer 2009;53:274–80.
  • Nieschlag E. Male hormonal contraception: love’s labour's lost? J Clin Endocrinol Metab 2009;94:1890–2.
  • Mallidis C, Agbaje I, O’Neill J, McClure N. The influence of type 1 diabetes mellitus on spermatogenic gene expression. Fertil Steril 2009;92:2085–7.
  • Lewejohann L, Damm OS, Luetjens CM, Hämäläinen T, Simoni M, Nieschlag E, Gromoll J, Wistuba J. Impaired recognition memory in male mice with a supernumerary X chromosome. Physiol Behav 2009;96:23–9.
  • Krausz C, Giachini C, Xue Y, O’Bryan MK, Gromoll J, Rajpert-de Meyts E, Oliva R, Aknin-Seifer I, Erdei E, Jorgensen N, et al. Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background. J Med Genet 2009;46:21–31.
  • Kossack N, Meneses J, Shefi S, Nguyen HN, Chavez S, Nicholas C, Gromoll J, Turek PJ, Reijo-Pera R a. Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells. Stem Cells 2009;27:138–49.
  • Kornmann B, Nieschlag E, Zitzmann M, Gromoll J, Simoni M, von Eckardstein S. Body fat content and testosterone pharmacokinetics determine gonadotropin suppression after intramuscular injections of testosterone preparations in normal men. J Androl 2009;30:602–13.
  • Kamischke A, Cordes T, Nieschlag E. [The diagnostic of male infertility - an important part of reproductive medicine]. Ther Umsch 2009;66:789–95.
  • Hose KA, Häffner K, Fietz D, Gromoll J, Eckert T, Kliesch S, Siebert H-C, Bergmann M. A novel sequence variation in the transactivation regulating domain of the human androgen receptor. Fertil Steril 2009;92:390.e9–390.e11.
  • Hartmann M, Siener R, Krege S, Schmelz H, Dieckmann K-P, Heidenreich A, Kwasny P, Pechoel M, Lehmann J, Kliesch S, et al. [Results of the randomised phase III study of the German Testicular Cancer Study Group. Retroperitoneal lymphadenectomy versus one cycle BEP as adjuvant therapy for non-seminomatous testicular tumours in clinical stage I]. Urologe A 2009;48:523–8.
  • Gassei K, Ehmcke J, Schlatt S. Efficient enrichment of undifferentiated GFR alpha 1+ spermatogonia from immature rat testis by magnetic activated cell sorting. Cell Tissue Res 2009;337:177–83.
  • Fowler P a, Bhattacharya S, Gromoll J, Monteiro A, O’Shaughnessy PJ. Maternal smoking and developmental changes in luteinizing hormone (LH) and the LH receptor in the fetal testis. J Clin Endocrinol Metab 2009;94:4688–95.
  • Fink C, Weigel R, Fink L, Wilhelm J, Kliesch S, Zeiler M, Bergmann M, Brehm R. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. Histochem Cell Biol 2009;131:755–64.
  • Cooper TG, Hellenkemper B. Method-related estimates of sperm vitality. J Androl 2009;30:214–8.

Publikationen 2008

  • Krege S, Beyer J, Souchon R, Albers P, Albrecht W, Algaba F, Bamberg M, Bodrogi I, Bokemeyer C, Cavallin-Ståhl E, et al. European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. Eur Urol 2008;53:478–96.
  • Zitzmann M. [Therapy of male hypogonadism]. Internist (Berl) 2008;49:559–60, 562–4, 566–9.
  • Zeschnigk M, Albrecht B, Buiting K, Kanber D, Eggermann T, Binder G, Gromoll J, Prott E-C, Seland S, Horsthemke B. IGF2/H19 hypomethylation in Silver-Russell syndrome and isolated hemihypoplasia. Eur J Hum Genet 2008;16:328–34.
  • Zerbetto I, Gromoll J, Luisi S, Reis FM, Nieschlag E, Simoni M, Petraglia F. Follicle-stimulating hormone receptor and DAZL gene polymorphisms do not affect the age of menopause. Fertil Steril 2008;90:2264–8.
  • Tüttelmann F, Gromoll J, Kliesch S. [Genetics of male infertility]. Urologe A 2008;47:1561–2, 1564–7.
  • Tarulli GA, Meachem SJ, Schlatt S, Stanton PG. Regulation of testicular tight junctions by gonadotrophins in the adult Djungarian hamster in vivo. Reproduction 2008;135:867–77.
  • Stukenborg J-B, Wistuba J, Luetjens CM, Elhija MA, Huleihel M, Lunenfeld E, Gromoll J, Nieschlag E, Schlatt S. Coculture of spermatogonia with somatic cells in a novel three-dimensional soft-agar-culture-system. J Androl 2008;29:312–29.
  • Steger K, Wilhelm J, Konrad L, Stalf T, Greb R, Diemer T, Kliesch S, Bergmann M, Weidner W. Both protamine-1 to protamine-2 mRNA ratio and Bcl2 mRNA content in testicular spermatids and ejaculated spermatozoa discriminate between fertile and infertile men. Hum Reprod 2008;23:11–6.
  • Simoni M, Tempfer CB, Destenaves B, Fauser BCJM. Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response. Hum Reprod Update 2008;14:459–84.
  • Shabsigh R, Arver S, Channer KS, Eardley I, Fabbri A, Gooren L, Heufelder A, Jones H, Meryn S, Zitzmann M. The triad of erectile dysfunction, hypogonadism and the metabolic syndrome. Int J Clin Pract 2008b;62:791–8.
  • Shabsigh R, Arver S, Channer KS, Eardley I, Fabbri A, Gooren L, Heufelder A, Jones H, Meryn S, Zitzmann M. Sexual health as a portal to men’s health: a problem turned around into an opportunity. Int J Clin Pract 2008a;62:179–81.
  • Schlatt S, Pohl CR, Ehmcke J, Ramaswamy S. Age-related changes in diurnal rhythms and levels of gonadotropins, testosterone, and inhibin B in male rhesus monkeys (Macaca mulatta). Biol Reprod 2008;79:93–9.
  • Oechsle K, Hartmann M, Brenner W, Venz S, Weissbach L, Franzius C, Kliesch S, Mueller S, Krege S, Heicappell R, et al. [18F]Fluorodeoxyglucose positron emission tomography in nonseminomatous germ cell tumors after chemotherapy: the German multicenter positron emission tomography study group. J Clin Oncol 2008;26:5930–5.
  • Müller T, Eildermann K, Dhir R, Schlatt S, Behr R. Glycan stem-cell markers are specifically expressed by spermatogonia in the adult non-human primate testis. Hum Reprod 2008;23:2292–8.
  • Mommers E, Kersemaekers WM, Elliesen J, Kepers M, Apter D, Behre HM, Beynon J, Bouloux PM, Costantino A, Gerbershagen H-P, et al. Male hormonal contraception: a double-blind, placebo-controlled study. J Clin Endocrinol Metab 2008;93:2572–80.
  • Kossack N, Simoni M, Richter-Unruh A, Themmen APN, Gromoll J. Mutations in a novel, cryptic exon of the luteinizing hormone/chorionic gonadotropin receptor gene cause male pseudohermaphroditism. PLoS Med 2008;5:e88.
  • Kliesch S, Cooper TG. [Semen analysis: spermiogram according to WHO criteria]. Urologe A 2008;47:1548, 1550–4.
  • Jacobeit JW, Kliesch S. [Gynecomastia: diagnosis and therapy]. Dtsch Med Wochenschr 2008;133:2567–71.
  • Hinz S, Schrader M, Kempkensteffen C, Bares R, Brenner W, Krege S, Franzius C, Kliesch S, Heicappel R, Miller K, et al. The role of positron emission tomography in the evaluation of residual masses after chemotherapy for advanced stage seminoma. J Urol 2008;179:936–40; discussion 940.
  • Henke A, Gromoll J. New insights into the evolution of chorionic gonadotrophin. Mol Cell Endocrinol 2008;291:11–9.
  • Gassei K, Ehmcke J, Schlatt S. Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay. Reproduction 2008;136:459–69.
  • Ehmcke J, Schlatt S. Identification and characterization of spermatogonial subtypes and their expansion in whole mounts and tissue sections from primate testes. Methods Mol Biol 2008b;450:109–18.
  • Ehmcke J, Schlatt S. Animal models for fertility preservation in the male. Reproduction 2008a;136:717–23.
  • Ehmcke J, Gassei K, Schlatt S. Ectopic testicular xenografts from newborn hamsters (Phodopus sungorus) show better spermatogenic activity in aged compared with young recipients. J Exp Zool A Ecol Genet Physiol 2008;309:278–87.
  • De Wit M, Brenner W, Hartmann M, Kotzerke J, Hellwig D, Lehmann J, Franzius C, Kliesch S, Schlemmer M, Tatsch K, et al. [18F]-FDG-PET in clinical stage I/II non-seminomatous germ cell tumours: results of the German multicentre trial. Ann Oncol 2008;19:1619–23.
  • Callies C, Cooper TG, Yeung CH. Channels for water efflux and influx involved in volume regulation of murine spermatozoa. Reproduction 2008;136:401–10.
  • Albers P, Siener R, Krege S, Schmelz H-U, Dieckmann K-P, Heidenreich A, Kwasny P, Pechoel M, Lehmann J, Kliesch S, et al. Randomized phase III trial comparing retroperitoneal lymph node dissection with one course of bleomycin and etoposide plus cisplatin chemotherapy in the adjuvant treatment of clinical stage I Nonseminomatous testicular germ cell tumors: AUO trial AH 01/94. J Clin Oncol 2008;26:2966–72.